Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
External IDs OMIM108960 MGI97371 HomoloGene37367 GeneCards: NPR1 Gene
EC number
RNA expression pattern
PBB GE NPR1 32625 at tn.png
PBB GE NPR1 204648 at tn.png
More reference expression data
Species Human Mouse
Entrez 4881 18160
Ensembl ENSG00000169418 ENSMUSG00000027931
UniProt P16066 Q2TAY4
RefSeq (mRNA) NM_000906 NM_008727.5
RefSeq (protein) NP_000897 NP_032753.5
Location (UCSC) Chr 1:
153.65 – 153.67 Mb
Chr 3:
90.25 – 90.27 Mb
PubMed search [1] [2]

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene.



NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP, respectively).[1]

It is localized in the kidney[2] where it results in natriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.[2]


Further reading

  • Pandey KN (2002). "Intracellular trafficking and metabolic turnover of ligand-bound guanylyl cyclase/atrial natriuretic peptide receptor-A into subcellular compartments.". Mol. Cell. Biochem. 230 (1–2): 61–72. doi:10.1023/A:1014240006767. PMID 11952097. 
  • Lucarelli K, Iacoviello M, Dessì-Fulgheri P, et al. (2003). "[Natriuretic peptides and essential arterial hypertension]". Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology 3 (11): 1085–91. PMID 12506509. 
  • Pandey KN (2005). "Internalization and trafficking of guanylyl cyclase/natriuretic peptide receptor-A". Peptides 26 (6): 985–1000. doi:10.1016/j.peptides.2004.12.020. PMID 15911067. 
  • Garg R, Pandey KN (2005). "Regulation of guanylyl cyclase/natriuretic peptide receptor-A gene expression". Peptides 26 (6): 1009–23. doi:10.1016/j.peptides.2004.09.022. PMID 15911069. 

See also

External links

Delta · Kappa · Mu · Nociceptin
Other neuropeptide receptors
Type I cytokine receptor Enzyme-linked receptor Other
Sigma (1, 2)
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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