Beta-ketoacyl-(acyl-carrier-protein) synthase III

In enzymology, a beta-ketoacyl- [acyl-carrier-protein] synthase III (EC number| is an enzyme that catalyzes the chemical reaction

:acetyl-CoA + malonyl- [acyl-carrier-protein] ightleftharpoons acetoacetyl- [acyl-carrier-protein] + CoA + CO2

Thus, the two substrates of this enzyme are acetyl-CoA and [malonyl- [acyl-carrier-protein] , whereas its 3 products are [acetoacetyl- [acyl-carrier-protein] , CoA, and CO2.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:malonyl- [acyl-carrier-protein] C-acyltransferase. Other names in common use include 3-oxoacyl:ACP synthase III, 3-ketoacyl-acyl carrier protein synthase III, KASIII, KAS III, FabH, beta-ketoacyl-acyl carrier protein synthase III, beta-ketoacyl-ACP synthase III, beta-ketoacyl (acyl carrier protein) synthase III, and beta-ketoacyl-acyl-carrier-protein synthase III. This enzyme participates in fatty acid biosynthesis.


* Neidhardt, F.C. (Ed.), Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd ed., vol. 1, ASM Press, Washington, DC, 1996, p. 612-636.

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