Beta-ketoacyl-acyl-carrier-protein synthase II

In enzymology, a beta-ketoacyl-acyl-carrier-protein synthase II (EC number|2.3.1.179) is an enzyme that catalyzes the chemical reaction

:(Z)-hexadec-11-enoyl- [acyl-carrier-protein] + malonyl- [acyl-carrier-protein] ightleftharpoons (Z)-3-oxooctadec-13-enoyl- [acyl-carrier-protein] + CO2 + [acyl-carrier-protein]

Thus, the two substrates of this enzyme are [(Z)-hexadec-11-enoyl- [acyl-carrier-protein] and [malonyl- [acyl-carrier-protein] , whereas its 3 products are [(Z)-3-oxooctadec-13-enoyl- [acyl-carrier-protein] , CO2, and [acyl-carrier-protein] .

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is (Z)-hexadec-11-enoyl- [acyl-carrier-protein] :malonyl- [acyl-carrier-pr otein] C-acyltransferase (decarboxylating). Other names in common use include KASII, KAS II, FabF, 3-oxoacyl-acyl carrier protein synthase I, and beta-ketoacyl-ACP synthase II. This enzyme participates in fatty acid biosynthesis.

References

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* Neidhardt, F.C. (Ed.), Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd ed., vol. 1, ASM Press, Washington, DC, 1996, p. 612-636.

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