Beta-ketoacyl-acyl-carrier-protein synthase I

In enzymology, a beta-ketoacyl-acyl-carrier-protein synthase I (EC number|2.3.1.41) is an enzyme that catalyzes the chemical reaction

:an acyl- [acyl-carrier-protein] + malonyl- [acyl-carrier-protein] ightleftharpoons a 3-oxoacyl- [acyl-carrier-protein] + CO2 + [acyl-carrier-protein]

Thus, the two substrates of this enzyme are [acyl- [acyl-carrier-protein] and [malonyl- [acyl-carrier-protein] , whereas its 3 products are [3-oxoacyl- [acyl-carrier-protein] , CO2, and [acyl-carrier-protein] .

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl- [acyl-carrier-protein] :malonyl- [acyl-carrier-protein] C-acyltransferase (decarboxylating). Other names in common use include beta-ketoacyl-ACP synthase I, beta-ketoacyl synthetase, beta-ketoacyl-ACP synthetase, beta-ketoacyl-acyl carrier protein synthetase, beta-ketoacyl- [acyl carrier protein] synthase, beta-ketoacylsynthase, condensing enzyme, 3-ketoacyl-acyl carrier protein synthase, fatty acid condensing enzyme, acyl-malonyl(acyl-carrier-protein)-condensing enzyme, acyl-malonyl acyl carrier protein-condensing enzyme, beta-ketoacyl acyl carrier protein synthase, 3-oxoacyl- [acyl-carrier-protein] synthase, 3-oxoacyl:ACP synthase I, KASI, KAS I, FabF1, and FabB. This enzyme participates in fatty acid biosynthesis.

tructural studies

As of late 2007, 56 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1B3N, PDB link|1DD8, PDB link|1E5M, PDB link|1EBL, PDB link|1EK4, PDB link|1F91, PDB link|1FJ4, PDB link|1FJ8, PDB link|1G5X, PDB link|1H4F, PDB link|1HN9, PDB link|1HND, PDB link|1HNH, PDB link|1HNJ, PDB link|1HNK, PDB link|1HZP, PDB link|1J3N, PDB link|1KAS, PDB link|1M1M, PDB link|1MZJ, PDB link|1MZS, PDB link|1OX0, PDB link|1OXH, PDB link|1TQY, PDB link|1U6E, PDB link|1U6S, PDB link|1UB7, PDB link|1W0I, PDB link|1ZOW, PDB link|2AHB, PDB link|2AJ9, PDB link|2ALM, PDB link|2AQ7, PDB link|2AQB, PDB link|2BUH, PDB link|2BUI, PDB link|2BYW, PDB link|2BYX, PDB link|2BYY, PDB link|2BYZ, PDB link|2BZ3, PDB link|2BZ4, PDB link|2C9H, PDB link|2EBD, PDB link|2EFT, PDB link|2GFV, PDB link|2GFW, PDB link|2GFX, PDB link|2GFY, PDB link|2GP6, PDB link|2GQD, PDB link|2GYO, PDB link|2IWY, PDB link|2IWZ, PDB link|2IX4, and PDB link|2PFF.

References

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* Neidhardt, F.C. (Ed.), Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd ed., vol. 1, ASM Press, Washington, DC, 1996, p. 612-636.

External links

::"The CAS registry number for this enzyme class is CAS registry|9077-10-5."

Gene Ontology (GO) codes


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