3-dehydroquinate synthase

In enzymology, a 3-dehydroquinate synthase (EC number|4.2.3.4) is an enzyme that catalyzes the chemical reaction

:3-deoxy-arabino-heptulonate 7-phosphate ightleftharpoons 3-dehydroquinate + phosphate

Hence, this enzyme has one substrate, 3-deoxy-arabino-heptulonate 7-phosphate, and two products, 3-dehydroquinate and phosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is 3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing 3-dehydroquinate-forming). Other names in common use include 5-dehydroquinate synthase, 5-dehydroquinic acid synthetase, dehydroquinate synthase, 3-dehydroquinate synthetase, 3-deoxy-arabino-heptulosonate-7-phosphate phosphate-lyase, (cyclizing), and 3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing). This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis. It employs one cofactor, cobalt.

tructural studies

As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1NR5, PDB link|1NRX, PDB link|1NUA, PDB link|1NVA, PDB link|1NVB, PDB link|1NVD, PDB link|1NVE, PDB link|1NVF, PDB link|1SG6, PDB link|1UJN, PDB link|1XAG, PDB link|1XAH, PDB link|1XAI, PDB link|1XAJ, and PDB link|1XAL.

References

*
*
*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|37211-77-1."

Gene Ontology (GO) codes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • List of EC numbers (EC 4) — This list contains a list of EC numbers for the fourth group, EC 4, lyases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 4.1: Carbon Carbon LyasesEC… …   Wikipedia

  • Шикиматный путь — Шикиматный путь  метаболический путь, промежуточным метаболитом которого является шикимовая кислота (шикимат). Шикиматный путь наряду с поликетидным (ацетатно малонатным) механизмом построения бензольных ядер отмечается как… …   Википедия

  • 3-Dehydroquinic acid — IUPAC name (1R,3R,4S) 1,3,4 trihydroxy 5 oxocyclohexanecarboxylic acid …   Wikipedia

  • Mitomycin — Preferred IUPAC name [6 Amino 8a methoxy 5 methyl 4,7 dioxo 1,1a,2,4,7,8,8a,8b octahydroazireno[2 ,3 :3,4]pyrrolo[1,2 a]indol 8 yl]me …   Wikipedia

  • Shikimic acid — Chembox new Name = Shikimic acid ImageFile = Shikimic acid skeletal.png ImageName = Chemical structure of shikimic acid ImageFile1 = Shikimic acid 3D balls.png ImageName1 = 3D model of shikimic acid IUPACName = (3 R ,4 S ,5 R ) 3,4,5 Trihydroxy 1 …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.