2-methylcitrate dehydratase

In enzymology, a 2-methylcitrate dehydratase (EC number|4.2.1.79) is an enzyme that catalyzes the chemical reaction

:(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate ightleftharpoons (Z)-but-2-ene-1,2,3-tricarboxylate + H2O

Hence, this enzyme has one substrate, (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate, and two products, (Z)-but-2-ene-1,2,3-tricarboxylate and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming] . Other names in common use include 2-methylcitrate hydro-lyase, PrpD, and 2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase. This enzyme participates in propanoate metabolism.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|1SZQ.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|80891-26-5."

Gene Ontology (GO) codes


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  • List of EC numbers (EC 4) — This list contains a list of EC numbers for the fourth group, EC 4, lyases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 4.1: Carbon Carbon LyasesEC… …   Wikipedia

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