Eukaryotic translation initiation factor 4 gamma

Eukaryotic translation initiation factor 4 gamma, 1, also known as EIF4G1, is a human gene.

PBB_Summary
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summary_text = The protein encoded by this gene is a component of the protein complex EIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms. [cite web | title = Entrez Gene: EIF4G1 eukaryotic translation initiation factor 4 gamma, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1981| accessdate = ]

References

ee also

*Rotavirus NSP3

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gingras AC, Raught B, Sonenberg N |title=eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. |journal=Annu. Rev. Biochem. |volume=68 |issue= |pages= 913–63 |year= 2000 |pmid= 10872469 |doi= 10.1146/annurev.biochem.68.1.913
*cite journal | author=Yan R, Rychlik W, Etchison D, Rhoads RE |title=Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma. |journal=J. Biol. Chem. |volume=267 |issue= 32 |pages= 23226–31 |year= 1992 |pmid= 1429670 |doi=
*cite journal | author=Yan R, Rhoads RE |title=Human protein synthesis initiation factor eIF-4 gamma is encoded by a single gene (EIF4G) that maps to chromosome 3q27-qter. |journal=Genomics |volume=26 |issue= 2 |pages= 394–8 |year= 1995 |pmid= 7601469 |doi=
*cite journal | author=Mader S, Lee H, Pause A, Sonenberg N |title=The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 4990–7 |year= 1995 |pmid= 7651417 |doi=
*cite journal | author=Pause A, Belsham GJ, Gingras AC, "et al." |title=Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. |journal=Nature |volume=371 |issue= 6500 |pages= 762–7 |year= 1994 |pmid= 7935836 |doi= 10.1038/371762a0
*cite journal | author=Lamphear BJ, Yan R, Yang F, "et al." |title=Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus. |journal=J. Biol. Chem. |volume=268 |issue= 26 |pages= 19200–3 |year= 1993 |pmid= 8396129 |doi=
*cite journal | author=Haghighat A, Mader S, Pause A, Sonenberg N |title=Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. |journal=EMBO J. |volume=14 |issue= 22 |pages= 5701–9 |year= 1996 |pmid= 8521827 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Lamphear BJ, Rhoads RE |title=A single amino acid change in protein synthesis initiation factor 4G renders cap-dependent translation resistant to picornaviral 2A proteases. |journal=Biochemistry |volume=35 |issue= 49 |pages= 15726–33 |year= 1997 |pmid= 8961935 |doi= 10.1021/bi961864t
*cite journal | author=Brass N, Heckel D, Sahin U, "et al." |title=Translation initiation factor eIF-4gamma is encoded by an amplified gene and induces an immune response in squamous cell lung carcinoma. |journal=Hum. Mol. Genet. |volume=6 |issue= 1 |pages= 33–9 |year= 1997 |pmid= 9002667 |doi=
*cite journal | author=Eberle J, Krasagakis K, Orfanos CE |title=Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro. |journal=Int. J. Cancer |volume=71 |issue= 3 |pages= 396–401 |year= 1997 |pmid= 9139875 |doi=
*cite journal | author=Imataka H, Sonenberg N |title=Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. |journal=Mol. Cell. Biol. |volume=17 |issue= 12 |pages= 6940–7 |year= 1997 |pmid= 9372926 |doi=
*cite journal | author=Gradi A, Imataka H, Svitkin YV, "et al." |title=A novel functional human eukaryotic translation initiation factor 4G. |journal=Mol. Cell. Biol. |volume=18 |issue= 1 |pages= 334–42 |year= 1998 |pmid= 9418880 |doi=
*cite journal | author=Piron M, Vende P, Cohen J, Poncet D |title=Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F. |journal=EMBO J. |volume=17 |issue= 19 |pages= 5811–21 |year= 1998 |pmid= 9755181 |doi= 10.1093/emboj/17.19.5811
*cite journal | author=Imataka H, Gradi A, Sonenberg N |title=A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. |journal=EMBO J. |volume=17 |issue= 24 |pages= 7480–9 |year= 1999 |pmid= 9857202 |doi= 10.1093/emboj/17.24.7480
*cite journal | author=Pyronnet S, Imataka H, Gingras AC, "et al." |title=Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. |journal=EMBO J. |volume=18 |issue= 1 |pages= 270–9 |year= 1999 |pmid= 9878069 |doi= 10.1093/emboj/18.1.270
*cite journal | author=Laroia G, Cuesta R, Brewer G, Schneider RJ |title=Control of mRNA decay by heat shock-ubiquitin-proteasome pathway. |journal=Science |volume=284 |issue= 5413 |pages= 499–502 |year= 1999 |pmid= 10205060 |doi=
*cite journal | author=Vary TC, Jefferson LS, Kimball SR |title=Amino acid-induced stimulation of translation initiation in rat skeletal muscle. |journal=Am. J. Physiol. |volume=277 |issue= 6 Pt 1 |pages= E1077–86 |year= 2000 |pmid= 10600798 |doi=
*cite journal | author=Cuesta R, Laroia G, Schneider RJ |title=Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes. |journal=Genes Dev. |volume=14 |issue= 12 |pages= 1460–70 |year= 2000 |pmid= 10859165 |doi=

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