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Ribosomal protein S6 kinase, 90kDa, polypeptide 1

Rendering based on PDB 2WNT.
External IDs OMIM601684 MGI104558 HomoloGene55703 GeneCards: RPS6KA1 Gene
EC number
RNA expression pattern
PBB GE RPS6KA1 203379 at tn.png
More reference expression data
Species Human Mouse
Entrez 6195 20111
Ensembl ENSG00000117676 ENSMUSG00000003644
UniProt Q15418 Q3TIM6
RefSeq (mRNA) NM_001006665.1 NM_009097.4
RefSeq (protein) NP_001006666.1 NP_033123.2
Location (UCSC) Chr 1:
26.86 – 26.9 Mb
Chr 4:
133.4 – 133.44 Mb
PubMed search [1] [2]

Ribosomal protein S6 kinase alpha-1 is an enzyme that in humans is encoded by the RPS6KA1 gene.[1]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]



RPS6KA1 has been shown to interact with YWHAB,[3] MAPK1,[4][5][6] IκBα,[7] TOB1[8] and TSC2.[9][10]

See also


  1. ^ Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M (Apr 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression". Am J Physiol 266 (2 Pt 1): C351–9. PMID 8141249. 
  2. ^ "Entrez Gene: RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6195. 
  3. ^ Cavet, Megan E; Lehoux Stephanie, Berk Bradford C (May. 2003). "14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity". J. Biol. Chem. (United States) 278 (20): 18376–83. doi:10.1074/jbc.M208475200. ISSN 0021-9258. PMID 12618428. 
  4. ^ Roux, Philippe P; Richards Stephanie A, Blenis John (Jul. 2003). "Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity". Mol. Cell. Biol. (United States) 23 (14): 4796–804. doi:10.1128/MCB.23.14.4796-4804.2003. ISSN 0270-7306. PMC 162206. PMID 12832467. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=162206. 
  5. ^ Eblen, Scott T; Kumar N Vinay, Shah Kavita, Henderson Michelle J, Watts Colin K W, Shokat Kevan M, Weber Michael J (Apr. 2003). "Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs". J. Biol. Chem. (United States) 278 (17): 14926–35. doi:10.1074/jbc.M300485200. ISSN 0021-9258. PMID 12594221. 
  6. ^ Smith, J A; Poteet-Smith C E, Malarkey K, Sturgill T W (Jan. 1999). "Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo". J. Biol. Chem. (UNITED STATES) 274 (5): 2893–8. doi:10.1074/jbc.274.5.2893. ISSN 0021-9258. PMID 9915826. 
  7. ^ Schouten, G J; Vertegaal A C, Whiteside S T, Israël A, Toebes M, Dorsman J C, van der Eb A J, Zantema A (Jun. 1997). "IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase". EMBO J. (ENGLAND) 16 (11): 3133–44. doi:10.1093/emboj/16.11.3133. ISSN 0261-4189. PMC 1169932. PMID 9214631. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169932. 
  8. ^ Suzuki, T; Matsuda S, Tsuzuku J K, Yoshida Y, Yamamoto T (Feb. 2001). "A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob". Genes Cells (England) 6 (2): 131–8. doi:10.1046/j.1365-2443.2001.00406.x. ISSN 1356-9597. PMID 11260258. 
  9. ^ Roux, Philippe P; Ballif Bryan A, Anjum Rana, Gygi Steven P, Blenis John (Sep. 2004). "Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase". Proc. Natl. Acad. Sci. U.S.A. (United States) 101 (37): 13489–94. doi:10.1073/pnas.0405659101. ISSN 0027-8424. PMC 518784. PMID 15342917. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=518784. 
  10. ^ Rolfe, Mark; McLeod Laura E, Pratt Phillip F, Proud Christopher G (Jun. 2005). "Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)". Biochem. J. (England) 388 (Pt 3): 973–84. doi:10.1042/BJ20041888. PMC 1183479. PMID 15757502. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1183479. 

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