3-oxoacid CoA-transferase

In enzymology, a 3-oxoacid CoA-transferase (EC number|2.8.3.5) is an enzyme that catalyzes the chemical reaction

:succinyl-CoA + a 3-oxo acid ightleftharpoons succinate + a 3-oxoacyl-CoA

Thus, the two substrates of this enzyme are succinyl-CoA and 3-oxo acid, whereas its two products are succinate and 3-oxoacyl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is succinyl-CoA:3-oxo-acid CoA-transferase. Other names in common use include 3-oxoacid coenzyme A-transferase, 3-ketoacid CoA-transferase, 3-ketoacid coenzyme A transferase, 3-oxo-CoA transferase, 3-oxoacid CoA dehydrogenase, acetoacetate succinyl-CoA transferase, acetoacetyl coenzyme A-succinic thiophorase, succinyl coenzyme A-acetoacetyl coenzyme A-transferase, and succinyl-CoA transferase. This enzyme participates in 3 metabolic pathways: synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, and butanoate metabolism.

tructural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1M3E, PDB link|1O9L, PDB link|1OOY, PDB link|1OOZ, PDB link|1OPE, PDB link|2NRB, and PDB link|2NRC.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9027-43-4."

Gene Ontology (GO) codes


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