3-oxoacid CoA-transferase

In enzymology, a 3-oxoacid CoA-transferase (EC number| is an enzyme that catalyzes the chemical reaction

:succinyl-CoA + a 3-oxo acid ightleftharpoons succinate + a 3-oxoacyl-CoA

Thus, the two substrates of this enzyme are succinyl-CoA and 3-oxo acid, whereas its two products are succinate and 3-oxoacyl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is succinyl-CoA:3-oxo-acid CoA-transferase. Other names in common use include 3-oxoacid coenzyme A-transferase, 3-ketoacid CoA-transferase, 3-ketoacid coenzyme A transferase, 3-oxo-CoA transferase, 3-oxoacid CoA dehydrogenase, acetoacetate succinyl-CoA transferase, acetoacetyl coenzyme A-succinic thiophorase, succinyl coenzyme A-acetoacetyl coenzyme A-transferase, and succinyl-CoA transferase. This enzyme participates in 3 metabolic pathways: synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, and butanoate metabolism.

tructural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1M3E, PDB link|1O9L, PDB link|1OOY, PDB link|1OOZ, PDB link|1OPE, PDB link|2NRB, and PDB link|2NRC.



External links

::"The CAS registry number for this enzyme class is CAS registry|9027-43-4."

Gene Ontology (GO) codes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • 3-oxoacid CoA-transferase — 3 oxo·ac·id CoA trans·fer·ase (ok″so asґid ko aґ transґfər ās) [EC] an enzyme of the transferase class that catalyzes the shift of coenzyme A (CoA) from succinyl CoA to acetoacetic acid to form acetoacetyl CoA; the… …   Medical dictionary

  • 3-oxoacid-CoA transferase — An enzyme catalyzing the reversible conversion of acetoacetyl CoA and succinate into succinyl CoA and acetoacetate; malonyl CoA can substitute for succinyl CoA and a few other 3 oxo acids for the acetoacetate; an important …   Medical dictionary

  • 3-ketoacid CoA transferase — 3 ke·to·ac·id CoA trans·fer·ase (ke″to asґid ko aґ transґfər ās) 3 oxoacid CoA transferase …   Medical dictionary

  • 3-ketoacid-CoA transferase — SYN: 3 oxoacid CoA transferase …   Medical dictionary

  • OXCT1 — 3 oxoacid CoA transferase 1 PDB rendering based on 1m3e …   Wikipedia

  • List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… …   Wikipedia

  • acetoacetyl-succinic thiophorase — SYN: 3 oxoacid CoA transferase …   Medical dictionary

  • Dihydrolipoyl transacetylase — dihydrolipoyllysine residue acetyltransferase Atomic structure of a single subunit of dihydrolipoyl transacetylase from Azotobacter vinelandii that makes up the structural core of the pyruvate dehydrogenase multienzyme complex.[1] …   Wikipedia

  • metabolism — /meuh tab euh liz euhm/, n. 1. Biol., Physiol. the sum of the physical and chemical processes in an organism by which its material substance is produced, maintained, and destroyed, and by which energy is made available. Cf. anabolism, catabolism …   Universalium

  • Dihydrolipoyl-Transacylase — Masse/Länge Primärstruktur 421 Aminosäuren …   Deutsch Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.