enzymology, a 3-oxoacid CoA-transferase (EC number|220.127.116.11) is an enzymethat catalyzes the chemical reaction
:succinyl-CoA + a 3-oxo acid succinate + a 3-oxoacyl-CoA
Thus, the two substrates of this enzyme are
succinyl-CoAand 3-oxo acid, whereas its two products are succinateand 3-oxoacyl-CoA.
This enzyme belongs to the family of
transferases, specifically the CoA-transferases. The systematic name of this enzyme class is succinyl-CoA:3-oxo-acid CoA-transferase. Other names in common use include 3-oxoacid coenzyme A-transferase, 3-ketoacid CoA-transferase, 3-ketoacid coenzyme A transferase, 3-oxo-CoA transferase, 3-oxoacid CoA dehydrogenase, acetoacetate succinyl-CoA transferase, acetoacetyl coenzyme A-succinic thiophorase, succinyl coenzyme A-acetoacetyl coenzyme A-transferase, and succinyl-CoA transferase. This enzyme participates in 3 metabolic pathways: synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, and butanoate metabolism.
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1M3E, PDB link|1O9L, PDB link|1OOY, PDB link|1OOZ, PDB link|1OPE, PDB link|2NRB, and PDB link|2NRC.
CAS registry numberfor this enzyme class is CAS registry|9027-43-4."
Gene Ontology (GO) codes
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