TPH2

Tryptophan hydroxylase 2, also known as TPH2, is a human gene.

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summary_text = Tryptophan hydroxylase (TPH; EC 1.14.16.4) is the rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine, or 5HT). 5HT is causally involved in numerous central nervous activities, and it has several functions in peripheral tissues, including the maintenance of vascular tone and gut motility. [supplied by OMIM] cite web | title = Entrez Gene: TPH2 tryptophan hydroxylase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=121278| accessdate = ]

ee also

* Tryptophan hydroxylase

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Walther DJ, Peter JU, Bashammakh S, "et al." |title=Synthesis of serotonin by a second tryptophan hydroxylase isoform. |journal=Science |volume=299 |issue= 5603 |pages= 76 |year= 2003 |pmid= 12511643 |doi= 10.1126/science.1078197
*cite journal | author=Walther DJ, Bader M |title=A unique central tryptophan hydroxylase isoform. |journal=Biochem. Pharmacol. |volume=66 |issue= 9 |pages= 1673–80 |year= 2003 |pmid= 14563478 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Zill P, Baghai TC, Zwanzger P, "et al." |title=SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. |journal=Mol. Psychiatry |volume=9 |issue= 11 |pages= 1030–6 |year= 2005 |pmid= 15124006 |doi= 10.1038/sj.mp.4001525
*cite journal | author=Breidenthal SE, White DJ, Glatt CE |title=Identification of genetic variants in the neuronal form of tryptophan hydroxylase (TPH2). |journal=Psychiatr. Genet. |volume=14 |issue= 2 |pages= 69–72 |year= 2005 |pmid= 15167691 |doi=
*cite journal | author=De Luca V, Mueller DJ, Tharmalingam S, "et al." |title=Analysis of the novel TPH2 gene in bipolar disorder and suicidality. |journal=Mol. Psychiatry |volume=9 |issue= 10 |pages= 896–7 |year= 2005 |pmid= 15197398 |doi= 10.1038/sj.mp.4001531
*cite journal | author=Harvey M, Shink E, Tremblay M, "et al." |title=Support for the involvement of TPH2 gene in affective disorders. |journal=Mol. Psychiatry |volume=9 |issue= 11 |pages= 980–1 |year= 2005 |pmid= 15263906 |doi= 10.1038/sj.mp.4001557
*cite journal | author=Zill P, Büttner A, Eisenmenger W, "et al." |title=Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. |journal=Biol. Psychiatry |volume=56 |issue= 8 |pages= 581–6 |year= 2005 |pmid= 15476687 |doi= 10.1016/j.biopsych.2004.07.015
*cite journal | author=Zhang X, Gainetdinov RR, Beaulieu JM, "et al." |title=Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. |journal=Neuron |volume=45 |issue= 1 |pages= 11–6 |year= 2005 |pmid= 15629698 |doi= 10.1016/j.neuron.2004.12.014
*cite journal | author=Coon H, Dunn D, Lainhart J, "et al." |title=Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2). |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=135 |issue= 1 |pages= 42–6 |year= 2005 |pmid= 15768392 |doi= 10.1002/ajmg.b.30168
*cite journal | author=Sheehan K, Lowe N, Kirley A, "et al." |title=Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD. |journal=Mol. Psychiatry |volume=10 |issue= 10 |pages= 944–9 |year= 2005 |pmid= 15940290 |doi= 10.1038/sj.mp.4001698
*cite journal | author=Shamir A, Shaltiel G, Levi I, "et al." |title=Postmortem parietal cortex TPH2 expression is not altered in schizophrenic, unipolar-depressed, and bipolar patients vs control subjects. |journal=J. Mol. Neurosci. |volume=26 |issue= 1 |pages= 33–7 |year= 2005 |pmid= 15968084 |doi=
*cite journal | author=Brown SM, Peet E, Manuck SB, "et al." |title=A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. |journal=Mol. Psychiatry |volume=10 |issue= 9 |pages= 884–8, 805 |year= 2005 |pmid= 16044172 |doi= 10.1038/sj.mp.4001716
*cite journal | author=Walitza S, Renner TJ, Dempfle A, "et al." |title=Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. |journal=Mol. Psychiatry |volume=10 |issue= 12 |pages= 1126–32 |year= 2006 |pmid= 16116490 |doi= 10.1038/sj.mp.4001734
*cite journal | author=Canli T, Congdon E, Gutknecht L, "et al." |title=Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. |journal=Journal of neural transmission (Vienna, Austria : 1996) |volume=112 |issue= 11 |pages= 1479–85 |year= 2006 |pmid= 16245070 |doi= 10.1007/s00702-005-0391-4
*cite journal | author=Mössner R, Freitag CM, Gutknecht L, "et al." |title=The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder. |journal=J. Psychopharmacol. (Oxford) |volume=20 |issue= 4 |pages= 547–52 |year= 2006 |pmid= 16401665 |doi= 10.1177/0269881106059704
*cite journal | author=De Luca V, Hlousek D, Likhodi O, "et al." |title=The interaction between TPH2 promoter haplotypes and clinical-demographic risk factors in suicide victims with major psychoses. |journal=Genes Brain Behav. |volume=5 |issue= 1 |pages= 107–10 |year= 2006 |pmid= 16436194 |doi= 10.1111/j.1601-183X.2005.00182.x
*cite journal | author=Delorme R, Durand CM, Betancur C, "et al." |title=No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects. |journal=Biol. Psychiatry |volume=60 |issue= 2 |pages= 202–3 |year= 2006 |pmid= 16581035 |doi= 10.1016/j.biopsych.2005.12.014
*cite journal | author=Carkaci-Salli N, Flanagan JM, Martz MK, "et al." |title=Functional domains of human tryptophan hydroxylase 2 (hTPH2). |journal=J. Biol. Chem. |volume=281 |issue= 38 |pages= 28105–12 |year= 2006 |pmid= 16864580 |doi= 10.1074/jbc.M602817200

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