Golgi associated, gamma adaptin ear containing, ARF binding protein 3, also known as GGA3, is a human gene.

section_title =
summary_text = This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Alternative splicing of this gene results in two transcript variants.cite web | title = Entrez Gene: GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Nagase T, Seki N, Tanaka A, "et al." |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167–74, 199–210 |year= 1996 |pmid= 8590280 |doi=
*cite journal | author=Hirst J, Lui WW, Bright NA, "et al." |title=A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome. |journal=J. Cell Biol. |volume=149 |issue= 1 |pages= 67–80 |year= 2000 |pmid= 10747088 |doi=
*cite journal | author=Dell'Angelica EC, Puertollano R, Mullins C, "et al." |title=GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. |journal=J. Cell Biol. |volume=149 |issue= 1 |pages= 81–94 |year= 2000 |pmid= 10747089 |doi=
*cite journal | author=Boman AL, Zhang C, Zhu X, Kahn RA |title=A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi. |journal=Mol. Biol. Cell |volume=11 |issue= 4 |pages= 1241–55 |year= 2000 |pmid= 10749927 |doi=
*cite journal | author=Takatsu H, Yoshino K, Nakayama K |title=Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin. |journal=Biochem. Biophys. Res. Commun. |volume=271 |issue= 3 |pages= 719–25 |year= 2000 |pmid= 10814529 |doi= 10.1006/bbrc.2000.2700
*cite journal | author=Puertollano R, Randazzo PA, Presley JF, "et al." |title=The GGAs promote ARF-dependent recruitment of clathrin to the TGN. |journal=Cell |volume=105 |issue= 1 |pages= 93–102 |year= 2001 |pmid= 11301005 |doi=
*cite journal | author=Puertollano R, Aguilar RC, Gorshkova I, "et al." |title=Sorting of mannose 6-phosphate receptors mediated by the GGAs. |journal=Science |volume=292 |issue= 5522 |pages= 1712–6 |year= 2001 |pmid= 11387475 |doi= 10.1126/science.1060750
*cite journal | author=Misra S, Puertollano R, Kato Y, "et al." |title=Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains. |journal=Nature |volume=415 |issue= 6874 |pages= 933–7 |year= 2002 |pmid= 11859375 |doi= 10.1038/415933a
*cite journal | author=Takatsu H, Yoshino K, Toda K, Nakayama K |title=GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors. |journal=Biochem. J. |volume=365 |issue= Pt 2 |pages= 369–78 |year= 2002 |pmid= 11950392 |doi= 10.1042/BJ20020428
*cite journal | author=Kato Y, Misra S, Puertollano R, "et al." |title=Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism. |journal=Nat. Struct. Biol. |volume=9 |issue= 7 |pages= 532–6 |year= 2002 |pmid= 12032548 |doi= 10.1038/nsb807
*cite journal | author=Doray B, Bruns K, Ghosh P, Kornfeld SA |title=Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 12 |pages= 8072–7 |year= 2002 |pmid= 12060753 |doi= 10.1073/pnas.082235699
*cite journal | author=Wasiak S, Legendre-Guillemin V, Puertollano R, "et al." |title=Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics. |journal=J. Cell Biol. |volume=158 |issue= 5 |pages= 855–62 |year= 2002 |pmid= 12213833 |doi= 10.1083/jcb.200205078
*cite journal | author=Doray B, Ghosh P, Griffith J, "et al." |title=Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network. |journal=Science |volume=297 |issue= 5587 |pages= 1700–3 |year= 2002 |pmid= 12215646 |doi= 10.1126/science.1075327
*cite journal | author=Boman AL, Salo PD, Hauglund MJ, "et al." |title=ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization. |journal=Mol. Biol. Cell |volume=13 |issue= 9 |pages= 3078–95 |year= 2003 |pmid= 12221117 |doi= 10.1091/mbc.E02-02-0078
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mattera R, Arighi CN, Lodge R, "et al." |title=Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex. |journal=EMBO J. |volume=22 |issue= 1 |pages= 78–88 |year= 2003 |pmid= 12505986 |doi= 10.1093/emboj/cdg015
*cite journal | author=Wakasugi M, Waguri S, Kametaka S, "et al." |title=Predominant expression of the short form of GGA3 in human cell lines and tissues. |journal=Biochem. Biophys. Res. Commun. |volume=306 |issue= 3 |pages= 687–92 |year= 2003 |pmid= 12810073 |doi=
*cite journal | author=He X, Zhu G, Koelsch G, "et al." |title=Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins. |journal=Biochemistry |volume=42 |issue= 42 |pages= 12174–80 |year= 2003 |pmid= 14567678 |doi= 10.1021/bi035199h
*cite journal | author=Ghosh P, Griffith J, Geuze HJ, Kornfeld S |title=Mammalian GGAs act together to sort mannose 6-phosphate receptors. |journal=J. Cell Biol. |volume=163 |issue= 4 |pages= 755–66 |year= 2004 |pmid= 14638859 |doi= 10.1083/jcb.200308038
*cite journal | author=Shiba Y, Katoh Y, Shiba T, "et al." |title=GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination. |journal=J. Biol. Chem. |volume=279 |issue= 8 |pages= 7105–11 |year= 2004 |pmid= 14660606 |doi= 10.1074/jbc.M311702200

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