FLNA


FLNA

Filamin A, alpha (actin binding protein 280), also known as FLNA, is a human gene.

PBB_Summary
section_title =
summary_text = Actin-binding protein, or filamin, is a 280-kD protein that crosslinks actin filaments into orthogonal networks in cortical cytoplasm and participates in the anchoring of membrane proteins for the actin cytoskeleton. Remodeling of the cytoskeleton is central to the modulation of cell shape and migration. Filamin A, encoded by the FLNA gene, is a widely expressed protein that regulates reorganization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes, and second messengers. [supplied by OMIM] [cite web | title = Entrez Gene: FLNA filamin A, alpha (actin binding protein 280)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2316| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Stossel TP, Condeelis J, Cooley L, "et al." |title=Filamins as integrators of cell mechanics and signalling. |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 2 |pages= 138–45 |year= 2001 |pmid= 11252955 |doi= 10.1038/35052082
*cite journal | author=van der Flier A, Sonnenberg A |title=Structural and functional aspects of filamins. |journal=Biochim. Biophys. Acta |volume=1538 |issue= 2-3 |pages= 99–117 |year= 2001 |pmid= 11336782 |doi=

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