REL

v-rel reticuloendotheliosis viral oncogene homolog (avian), also known as REL, is a human gene. The protein encoded by the human REL gene is a member of the NF-κB family of transcription factors. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphomas and Hodgkin's lymphomas.

Further reading

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citations =
*cite journal | author=Rayet B, Gélinas C |title=Aberrant rel/nfkb genes and activity in human cancer. |journal=Oncogene |volume=18 |issue= 49 |pages= 6938–47 |year= 2000 |pmid= 10602468 |doi= 10.1038/sj.onc.1203221
*cite journal | author=Kunsch C, Ruben SM, Rosen CA |title=Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation. |journal=Mol. Cell. Biol. |volume=12 |issue= 10 |pages= 4412–21 |year= 1992 |pmid= 1406630 |doi=
*cite journal | author=Neumann M, Tsapos K, Scheppler JA, "et al." |title=Identification of complex formation between two intracellular tyrosine kinase substrates: human c-Rel and the p105 precursor of p50 NF-kappa B. |journal=Oncogene |volume=7 |issue= 11 |pages= 2095–104 |year= 1992 |pmid= 1437141 |doi=
*cite journal | author=Kochel T, Rice NR |title=v-rel- and c-rel-protein complexes bind to the NF-kappa B site in vitro. |journal=Oncogene |volume=7 |issue= 3 |pages= 567–72 |year= 1992 |pmid= 1549370 |doi=
*cite journal | author=Ruben SM, Klement JF, Coleman TA, "et al." |title=I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity. |journal=Genes Dev. |volume=6 |issue= 5 |pages= 745–60 |year= 1992 |pmid= 1577270 |doi=
*cite journal | author=Kumar S, Rabson AB, Gélinas C |title=The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein. |journal=Mol. Cell. Biol. |volume=12 |issue= 7 |pages= 3094–106 |year= 1992 |pmid= 1620118 |doi=
*cite journal | author=Lu D, Thompson JD, Gorski GK, "et al." |title=Alterations at the rel locus in human lymphoma. |journal=Oncogene |volume=6 |issue= 7 |pages= 1235–41 |year= 1991 |pmid= 1650444 |doi=
*cite journal | author=Muchardt C, Seeler JS, Nirula A, "et al." |title=Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products. |journal=J. Virol. |volume=66 |issue= 1 |pages= 244–50 |year= 1992 |pmid= 1727488 |doi=
*cite journal | author=Hansen SK, Nerlov C, Zabel U, "et al." |title=A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene. |journal=EMBO J. |volume=11 |issue= 1 |pages= 205–13 |year= 1992 |pmid= 1740106 |doi=
*cite journal | author=Davis N, Ghosh S, Simmons DL, "et al." |title=Rel-associated pp40: an inhibitor of the rel family of transcription factors. |journal=Science |volume=253 |issue= 5025 |pages= 1268–71 |year= 1991 |pmid= 1891714 |doi=
*cite journal | author=Lim MY, Davis N, Zhang JY, Bose HR |title=The v-rel oncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70. |journal=Virology |volume=175 |issue= 1 |pages= 149–60 |year= 1990 |pmid= 2155506 |doi=
*cite journal | author=Brownell E, Mittereder N, Rice NR |title=A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon. |journal=Oncogene |volume=4 |issue= 7 |pages= 935–42 |year= 1989 |pmid= 2666912 |doi=
*cite journal | author=Brownell E, O'Brien SJ, Nash WG, Rice N |title=Genetic characterization of human c-rel sequences. |journal=Mol. Cell. Biol. |volume=5 |issue= 10 |pages= 2826–31 |year= 1986 |pmid= 3016517 |doi=
*cite journal | author=Brownell E, Kozak CA, Fowle JR, "et al." |title=Comparative genetic mapping of cellular rel sequences in man, mouse, and the domestic cat. |journal=Am. J. Hum. Genet. |volume=39 |issue= 2 |pages= 194–202 |year= 1986 |pmid= 3529946 |doi=
*cite journal | author=John S, Reeves RB, Lin JX, "et al." |title=Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins. |journal=Mol. Cell. Biol. |volume=15 |issue= 3 |pages= 1786–96 |year= 1995 |pmid= 7862168 |doi=
*cite journal | author=Xu X, Gélinas C |title=The v-Rel oncoprotein complexes with new Rel- and RelA-related proteins in transformed cells. |journal=Virology |volume=207 |issue= 2 |pages= 362–8 |year= 1995 |pmid= 7886940 |doi= 10.1006/viro.1995.1095
*cite journal | author=Mackman N |title=Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers. |journal=J. Biol. Chem. |volume=269 |issue= 42 |pages= 26363–7 |year= 1994 |pmid= 7929355 |doi=
*cite journal | author=Sif S, Gilmore TD |title=Interaction of the v-Rel oncoprotein with cellular transcription factor Sp1. |journal=J. Virol. |volume=68 |issue= 11 |pages= 7131–8 |year= 1994 |pmid= 7933095 |doi=
*cite journal | author=Hansen SK, Baeuerle PA, Blasi F |title=Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription. |journal=Mol. Cell. Biol. |volume=14 |issue= 4 |pages= 2593–603 |year= 1994 |pmid= 8139561 |doi=
*cite journal | author=Beg AA, Baldwin AS |title=Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor. |journal=Oncogene |volume=9 |issue= 5 |pages= 1487–92 |year= 1994 |pmid= 8152812 |doi=

External links

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  • -rel — also erel, dim. or depreciatory suffix, in some cases from O.Fr. erel (Mod.Fr. ereau) or erelle, but in most cases used with native stems …   Etymology dictionary

  • rel — abbrev. 1. relating 2. relative 3. relatively 4. religion …   English World dictionary

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