TNNI3


TNNI3

Troponin I type 3 (cardiac), also known as TNNI3, is a human gene.

PBB_Summary
section_title =
summary_text = Troponin I (TnI) is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle; see also TNNI1 (MIM 191042). The others are troponin T (TnT; see MIM 191041) and troponin C (TnC; see MIM 191040). [supplied by OMIM] cite web | title = Entrez Gene: TNNI3 troponin I type 3 (cardiac)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7137| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ni CY |title=Cardiac troponin I: a biomarker for detection and risk stratification of minor myocardial damage. |journal=Clin. Lab. |volume=47 |issue= 9-10 |pages= 483–92 |year= 2002 |pmid= 11596911 |doi=
*cite journal | author=Hunkeler NM, Kullman J, Murphy AM |title=Troponin I isoform expression in human heart. |journal=Circ. Res. |volume=69 |issue= 5 |pages= 1409–14 |year= 1991 |pmid= 1934363 |doi=
*cite journal | author=MacGeoch C, Barton PJ, Vallins WJ, "et al." |title=The human cardiac troponin I locus: assignment to chromosome 19p13.2-19q13.2. |journal=Hum. Genet. |volume=88 |issue= 1 |pages= 101–4 |year= 1992 |pmid= 1959915 |doi=
*cite journal | author=Vallins WJ, Brand NJ, Dabhade N, "et al." |title=Molecular cloning of human cardiac troponin I using polymerase chain reaction. |journal=FEBS Lett. |volume=270 |issue= 1-2 |pages= 57–61 |year= 1990 |pmid= 2226790 |doi=
*cite journal | author=Mittmann K, Jaquet K, Heilmeyer LM |title=A common motif of two adjacent phosphoserines in bovine, rabbit and human cardiac troponin I. |journal=FEBS Lett. |volume=273 |issue= 1-2 |pages= 41–5 |year= 1990 |pmid= 2226863 |doi=
*cite journal | author=Noland TA, Raynor RL, Kuo JF |title=Identification of sites phosphorylated in bovine cardiac troponin I and troponin T by protein kinase C and comparative substrate activity of synthetic peptides containing the phosphorylation sites. |journal=J. Biol. Chem. |volume=264 |issue= 34 |pages= 20778–85 |year= 1990 |pmid= 2584239 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Armour KL, Harris WJ, Tempest PR |title=Cloning and expression in Escherichia coli of the cDNA encoding human cardiac troponin I. |journal=Gene |volume=131 |issue= 2 |pages= 287–92 |year= 1993 |pmid= 8406024 |doi=
*cite journal | author=Bhavsar PK, Brand NJ, Yacoub MH, Barton PJ |title=Isolation and characterization of the human cardiac troponin I gene (TNNI3). |journal=Genomics |volume=35 |issue= 1 |pages= 11–23 |year= 1996 |pmid= 8661099 |doi= 10.1006/geno.1996.0317
*cite journal | author=Jideama NM, Noland TA, Raynor RL, "et al." |title=Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 23277–83 |year= 1996 |pmid= 8798526 |doi=
*cite journal | author=Takeda S, Kobayashi T, Taniguchi H, "et al." |title=Structural and functional domains of the troponin complex revealed by limited digestion. |journal=Eur. J. Biochem. |volume=246 |issue= 3 |pages= 611–7 |year= 1997 |pmid= 9219516 |doi=
*cite journal | author=Kimura A, Harada H, Park JE, "et al." |title=Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. |journal=Nat. Genet. |volume=16 |issue= 4 |pages= 379–82 |year= 1997 |pmid= 9241277 |doi= 10.1038/ng0897-379
*cite journal | author=Keane NE, Quirk PG, Gao Y, "et al." |title=The ordered phosphorylation of cardiac troponin I by the cAMP-dependent protein kinase--structural consequences and functional implications. |journal=Eur. J. Biochem. |volume=248 |issue= 2 |pages= 329–37 |year= 1997 |pmid= 9346285 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Vassylyev DG, Takeda S, Wakatsuki S, "et al." |title=Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 9 |pages= 4847–52 |year= 1998 |pmid= 9560191 |doi=
*cite journal | author=Mogensen J, Kruse TA, Børglum AD |title=Assignment of the human cardiac troponin I gene (TNNI3) to chromosome 19q13.4 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 3-4 |pages= 272–3 |year= 1998 |pmid= 9605869 |doi=
*cite journal | author=Barton PJ, Cullen ME, Townsend PJ, "et al." |title=Close physical linkage of human troponin genes: organization, sequence, and expression of the locus encoding cardiac troponin I and slow skeletal troponin T. |journal=Genomics |volume=57 |issue= 1 |pages= 102–9 |year= 1999 |pmid= 10191089 |doi= 10.1006/geno.1998.5702
*cite journal | author=Li MX, Spyracopoulos L, Sykes BD |title=Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C. |journal=Biochemistry |volume=38 |issue= 26 |pages= 8289–98 |year= 1999 |pmid= 10387074 |doi= 10.1021/bi9901679
*cite journal | author=Redwood C, Lohmann K, Bing W, "et al." |title=Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein. |journal=Circ. Res. |volume=86 |issue= 11 |pages= 1146–52 |year= 2000 |pmid= 10850966 |doi=
*cite journal | author=Ward DG, Ashton PR, Trayer HR, Trayer IP |title=Additional PKA phosphorylation sites in human cardiac troponin I. |journal=Eur. J. Biochem. |volume=268 |issue= 1 |pages= 179–85 |year= 2001 |pmid= 11121119 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Troponina I — tipo 1 (músculo esquelético, lenta) HUGO 11945 Símbolo TNNI1 Datos genéticos …   Wikipedia Español

  • Hypertrophic cardiomyopathy — Classification and external resources ICD 10 I42.1–I42.2 ICD 9 …   Wikipedia

  • Dilated cardiomyopathy — Classification and external resources ICD 10 I42.0 ICD 9 425.4 …   Wikipedia

  • Troponin I — is a part of the troponin complex. It binds to actin in thin myofilaments to hold the troponin tropomyosin complex in place. The letter I is given due to its inhibitory character.The tissue specific subtypes are: * Slow twitch skeletal muscle… …   Wikipedia

  • RCAN3 — Down syndrome critical region gene 1 like 2, also known as DSCR1L2, is a human gene.cite web | title = Entrez Gene: DSCR1L2 Down syndrome critical region gene 1 like 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • Kardiales Troponin — (Abk.: cT, oft auch einfach nur: Troponin) ist ein Proteinkomplex, welcher aus den Muskelzellen des Herzens bei Schädigung (z. B. beim Herzinfarkt) in das Blut freigesetzt wird. Der Nachweis eines erhöhten Troponinspiegels im Blut kann einen …   Deutsch Wikipedia

  • Rho-Kinase — 1 Größe 1354 Aminosäuren Bezeichner Gen Name …   Deutsch Wikipedia

  • Rho-Kinase 1 — Masse/Länge Primärstruktur 1354 Aminosäuren …   Deutsch Wikipedia

  • Troponina — La troponina es una proteína globular de gran peso molecular presente en el músculo estriado y en el músculo cardiaco. Modelo 3D del complejo de la troponina (troponina T en lila, I en azul y C en verde). Contenido 1 …   Wikipedia Español

  • Calciumstoffwechsel — Übergeordnet Ionen Homöostase Gene Ontology …   Deutsch Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.