Betaxolol


Betaxolol

drugbox


IUPAC_name = 1- [4- [2-(cyclopropylmethoxy)
ethyl] phenoxy] -3-
(1-methylethylamino)propan-2-ol
CAS_number = 63659-18-7
ATC_prefix=C07
ATC_suffix=AB05
ATC_supplemental=ATC|S01|ED02
PubChem=2369
ChemSpiderID=2279
DrugBank=APRD00245
C=18 | H=29 | N=1 | O=3
molecular_weight = 307.428 g/mol
bioavailability = 89%
metabolism = Hepatic
elimination_half-life = 14-22hours
excretion = Renal (20%)
pregnancy_AU = C
pregnancy_US = C
pregnancy_category =
legal_status = Rx-only
routes_of_administration = oral, ocular

Betaxolol (trade names Betoptic, Betoptic S, Lokren, Kerlone) is a selective beta1 receptor blocker used in the treatment of hypertension and glaucoma. Being selective for beta1 receptors, it typically has fewer systemic side effects than non-selective beta-blockers, for example, not causing bronchospasm (mediated by beta2 receptors) as timolol may. Betaxolol also shows greater affininty for beta1 receptors than metoprolol. In addition to its effect on the heart, betaxolol reduces the pressure within the eye (intraocular pressure). This effect is thought to be caused by reducing the production of the liquid (which is called the aqueous humor) within the eye. The precise mechanism of this effect is not known. The reduction in intraocular pressure reduces the risk of damage to the optic nerve and loss of vision in patients with elevated intraocular pressure due to glaucoma.

Betaxolol was approved by the U.S. Food and Drug Administration (FDA) for ocular use as a 0.5% solution (Betoptic) in 1985 and as a 0.25% solution (Betoptic S) in 1989.

Clinical uses

* Oral: for the management of hypertension
* Ophthalmic: for the management of glaucoma

Dosage

* Oral: The initial dose in hypertension is ordinarily 10 mg once daily either alone or added to diuretic therapy.
* Ophthalmic: The recommended dose is one to two drops in the affected eye(s) twice daily.

Contraindications

* Hypersensitivity to the drug
* Patients with sinus bradycardia, heart block greater than first degree, cardiogenic shock, and overt cardiac failure

External links

* [http://products.sanofi-aventis.us/kerlone/kerlone.pdf Kerlone prescribing information]

ee also

Levobetaxolol


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Look at other dictionaries:

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  • betaxolol — Eng. Betaxolol Betabloqueante cardioselectivo utilizado en Oftalmología para el tratamiento del glaucoma crónico de ángulo abierto y todas aquellas circunstancias que cursan con aumento de la presión intraocular …   Diccionario de oftalmología

  • betaxolol — noun A topical sympatholytic agent used to reduce ocular hypertension in the treatment of glaucoma …   Wiktionary

  • betaxolol — n. a beta blocker drug used to treat high blood pressure and chronic simple glaucoma. It is administered by mouth and as eye drops. Possible side effects include breathing difficulty, fatigue, cold extremities, and sleep disturbances. Trade names …   Medical dictionary

  • betaxolol — n. a beta blocker administered as eye drops to treat chronic simple glaucoma. Possible side effects are local stinging and burning. Trade names: Betoptic …   The new mediacal dictionary

  • betaxolol hydrochloride — A β adrenergic blocking agent used primarily in the treatment of ocular hypertension and chronic open angle glaucoma. * * * be·tax·o·lol hy·dro·chlo·ride (ba takґsə lol) [USP] a cardioselective beta adrenergic blocking agent that acts at… …   Medical dictionary

  • clorhidrato de betaxolol — Fármaco tópico prescrito para el alivio de la hipertensión ocular y el glaucoma crónico de ángulo abierto. Diccionario Mosby Medicina, Enfermería y Ciencias de la Salud, Ediciones Hancourt, S.A. 1999 …   Diccionario médico

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  • БЕТАКСОЛОЛ — (betaxolol) лекарственный препарат из группы бета блокаторов. Применяется для лечения гипертензии и хронической неосложненной глаукомы. Назначается внутрь или в глазных каплях. Возможные побочные эффекты: затруднение дыхания, повышенная… …   Толковый словарь по медицине

  • Beta blocker — Beta blockers Drug class Skeletal formula of propranolol, the first clinically successful beta blocker ATC code C07 …   Wikipedia


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