Signet ring cell

In histology, a signet ring cell is a malignant cell type seen predominantly in carcinomas. Signet ring cells are most frequently associated with stomach cancer, [Cancer Research UK. Signet Ring Cancer. URL: [] . Accessed on: November 2, 2007.] but can arise from any number of tissues including the prostate, [cite journal |author=Leong FJ, Leong AS, Swift J |title=Signet-ring carcinoma of the prostate |journal=Pathol. Res. Pract. |volume=192 |issue=12 |pages=1232–8; discussion 1239–41 |year=1996 |pmid=9182294 |doi=] bladder, gallbladder, [cite journal |author=Jain V, Gupta K, Kudva R, Rodrigues GS |title=A case of ovarian metastasis of gallbladder carcinoma simulating primary ovarian neoplasm: diagnostic pitfalls and review of literature |journal=Int. J. Gynecol. Cancer |volume=16 Suppl 1 |issue= |pages=319–21 |year=2006 |pmid=16515613 |doi=10.1111/j.1525-1438.2006.00335.x] breast, colon, [cite journal |author=Makino T, Tsujinaka T, Mishima H, "et al" |title=Primary signet-ring cell carcinoma of the colon and rectum: report of eight cases and review of 154 Japanese cases |journal=Hepatogastroenterology |volume=53 |issue=72 |pages=845–9 |year=2006 |pmid=17153438 |doi=] ovarian stroma and testis. [cite journal |author=Michal M, Hes O, Kazakov DV |title=Primary signet-ring stromal tumor of the testis |journal=Virchows Arch. |volume=447 |issue=1 |pages=107–10 |year=2005 |pmid=15909171 |doi=10.1007/s00428-005-1218-2]


The name of the cell comes from its appearance; signet ring cells resemble signet rings. They contain a large amount of mucin, which pushes the nucleus to the cell periphery. The pool of mucin in a signet ring cell mimics the appearance of a finger hole and the nucleus mimics the appearance of the face of the ring in profile.

Diagnostic significance

A significant number of signet ring cells, generally, are associated with a worse prognosis. [cite journal |author=Lee WS, Chun HK, Lee WY, "et al" |title=Treatment outcomes in patients with signet ring cell carcinoma of the colorectum |journal=Am. J. Surg. |volume=194 |issue=3 |pages=294–8 |year=2007 |pmid=17693269 |doi=10.1016/j.amjsurg.2006.12.041] [Cabebe EC, Mehta VK, Fisher G. Gastric Cancer. URL: [] . Accessed on: November 8, 2007.]


SRC carcinomas can be classified using immunohistochemistry. [cite journal |author=Tian MM, Zhao AL, Li ZW, Li JY |title=Phenotypic classification of gastric signet ring cell carcinoma and its relationship with clinicopathologic parameters and prognosis |journal=World J. Gastroenterol. |volume=13 |issue=23 |pages=3189–98 |year=2007 |pmid=17589897 |doi=]


External links

* [ Signet ring cells] -
* [ of a signet ring] -
* [ Signet ring cell definition] -

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • signet ring cell — n a cell that has its nucleus shifted to one side by a large cytoplasmic vacuole and that occurs esp. in mucin producing adenocarcinomas esp. of the stomach * * * a cell in which the nucleus has been pressed to one side by an accumulation of… …   Medical dictionary

  • signet-ring cell — Cell (adipocyte) with a large central fat filled vacuole that pushes the nucleus to one side to give an appearance reminiscent of a signet ring …   Dictionary of molecular biology

  • Signet ring cell carcinoma — Infobox Disease Name = PAGENAME Caption = Gastric signet ring cell carcinoma. H E stain. DiseasesDB = ICD10 = ICD9 = ICDO = 8490/3 OMIM = MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = D018279Signet ring cell carcinoma is an epilethial… …   Wikipedia

  • signet ring cell carcinoma — a type of highly malignant, mucus secreting tumor usually found in the stomach or intestine; the mucus secreting cells called signet ring cells are anaplastic …   Medical dictionary

  • signet ring cell carcinoma — A highly malignant type of cancer typically found in glandular cells that line the digestive organs. The cells resemble signet rings when examined under a microscope …   English dictionary of cancer terms

  • signet ring — n a malaria parasite in an intracellular developmental stage in which the nucleus is peripheral and the cytoplasm somewhat attenuated and annular * * * 1. a ring that has a much thicker portion; see under cell. 2. ring form …   Medical dictionary

  • signet cell — sig·net cell sig nət n SIGNET RING CELL …   Medical dictionary

  • Cell — The basic structural and functional unit in people and all living things. Each cell is a small container of chemicals and water wrapped in a membrane. Each cell in the human body there are 100 trillion cells in each of us contains the entire… …   Medical dictionary

  • ring form — the early trophozoite in the erythrocytic stage of the life cycle of hemosporian protozoa, which after Romanovsky staining has blue cytoplasm surrounding a clear zone with a red nucleus at one side, giving the cell the appearance of a signet ring …   Medical dictionary

  • ring — 1. A circular band surrounding a wide central opening; a r. shaped or circular structure surrounding an opening or level area. SYN: anulus [TA]. 2. The closed ( i.e., endless) chain of atoms in a cyclic compound; commonly used for “cyclic” or… …   Medical dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.