IUPAC_name = 4-amino-3-hydroxybutanoic acid
width = 200
width = 180
CAS_number = 352-21-6
ChemSpiderID = 2064
PubChem = 2149
molecular_weight = 119.12 g/mol
Gamma-amino-beta-hydroxybutyric acid (GABOB) is a derivative of the neurotransmitter
GABA. It is found naturally in the human body but it is not known whether it has an important physiological role at normal concentrations.
anticonvulsantproperties, [Chemello R, Giaretta D, Pellegrini A, Testa G. Effect of gamma-amino-beta-hydroxybutyric acid (GABHB) on experimentally-induced epileptic activity. (Italian). "Rivista di Neurologia". 1980 Jul-Aug;50(4):253-68.] but is of relatively low potency when used by itself, and is more useful as an adjutant treatment used alongside another anticonvulsant drug. [García-Flores E, Farías R. gamma-Amino-beta-hydroxybutyric acid as add-on therapy in adult patients with severe focal epilepsy. "Stereotactic and Functional Neurosurgery". 1997;69(1-4 Pt 2):243-6.] It has two stereoisomers, with the (3S) isomer d-GABOB being around twice as potent an anticonvulsant as the (3R) isomer l-GABOB. [Roberts E, Krause DN, Wong E, Mori A. Different efficacies of d- and l-gamma-amino-beta-hydroxybutyric acids in GABA receptor and transport test systems. "Journal of Neuroscience". 1981 Feb;1(2):132-40.]
Other studies have suggested it may produce improved learning and memory function, [Banfi S, Fonio W, Allievi E, Pinza M, Dorigotti L. Cyclic GABA-GABOB analogues. IV. Activity on learning and memory. "Il Farmaco; Edizione Scientifica". 1984 Jan;39(1):16-22.] probably through a cholinergic mechanism, [Yano S, Mizuno M, Watanabe K. Stimulatory effect of some therapeutic drugs used for improving cerebral insufficiency on gastric acid secretion in rats. "Pharmacology". 1990;40(4):205-10.] as well as boosting
growth hormonerelease. [Fioretti P, Melis GB, Paoletti AM, Parodo G, Caminiti F, Corsini GU, Martini L. Gamma-amino-beta-hydroxy butyric acid stimulates prolactin and growth hormone release in normal women. "Journal of Clinical Endocrinology and Metabolism". 1978 Dec;47(6):1336-40.] [Takahara J, Yunoki S, Yakushiji W, Yamauchi J, Hosogi H, Ofuji T. Stimulatory effects of gamma-aminohydroxybutyric acid (GABOB) on growth hormone, prolactin and cortisol release in man. "Hormone and Metabolic Research". 1980 Jan;12(1):31-4.] [Melis GB, Paoletti AM, Mais V, Mastrapasqua NM, Strigini F, Fruzzetti F, Guarnieri G, Gambacciani M, Fioretti P. Dose-related effects of gamma-amino beta-hydroxy butyric acid (GABOB) infusion on growth hormone secretion in normal women. "Journal of Endocrinological Investigation". 1982 Mar-Apr;5(2):101-6.] However its effectiveness for these purposes has not been well established and it is not widely used in medicine, although it is sold as a dietary supplement.
Wikimedia Foundation. 2010.
Look at other dictionaries:
Gamma-Hydroxybutyric acid — γ Hydroxybutyric acid Systematic (IUPAC) name 4 Hydroxybutanoic acid … Wikipedia
Gamma-aminobutyric acid — Chembox new ImageFile=Gamma Aminobuttersäure gamma aminobutyric acid.svg ImageSize=230 ImageFile2=GABA3d.png IUPACName=4 aminobutanoic acid OtherNames= Section1= Chembox Identifiers CASNo=56 12 2 PubChem=119 ChemSpiderID = 116 SMILES=C(CC(=O)O)CN … Wikipedia
GABOA — gamma amino beta hydroxybutyric acid … Medical dictionary
GABOA — • gamma amino beta hydroxybutyric acid … Dictionary of medical acronyms & abbreviations
Phencyclidine — Systematic (IUPAC) name … Wikipedia
Neramexane — Systematic (IUPAC) name 1,3,3,5,5 pentamethylcyclohexanamine Clinical data Pregnancy cat. ? … Wikipedia
Arylcyclohexylamine — Phencyclidine, the prototypal arylcyclohexylamine derivative. Arylcyclohexylamines, also known as arylcyclohexamines or arylcyclohexanamines, are a chemical class of pharmaceutical, designer, and experimental drugs. Contents … Wikipedia
Nitrous oxide — N2O redirects here. For other uses, see N2O (disambiguation). Laughing gas redirects here. For other uses, see Laughing gas (disambiguation). Not to be confused with nitric oxide (formula NO) or nitrogen dioxide (formula NO2). For other uses, see … Wikipedia
Dieticyclidine — Systematic (IUPAC) name N,N diethyl 1 phenylcyclohexan 1 amine Clinical data Pregnancy cat. ? … Wikipedia