Otto Folin

Otto Folin

Otto Folin in biochemistry lab at McLean Hospital, 1905; photo by A.H. Folsom (Harvard)
Born April 4, 1867(1867-04-04)
Åseda, Småland, Sweden
Died October 23, 1934(1934-10-23) (aged 67)
Fields biochemistry
Alma mater University of Minnesota
University of Chicago
Doctoral advisor Albrecht Kossel
Doctoral students Edward Adelbert Doisy
George H. Hitchings
James Batcheller Sumner

Otto Knut Olof Folin ( April 4, 1867 – October 25, 1934) was a Swedish-born American chemist who is best known for his groundbreaking work at Harvard University on practical micromethods for the determination of the constituents of protein-free blood filtrates and the discovery of creatine phosphate in muscles.



Folin was born in Åseda, Småland in Sweden, the son of Nils Magnus Folin and Eva Olson. He moved to America at the age of fifteen following two brothers and an aunt who had already settled there. He carried on his schooling in Stillwater. He moved to Minneapolis, Minnesota entering the University of Minnesota and completed his B.S in 1892. In 1890, he became a citizen of the United States. He joined the University of Chicago gaining his Ph.D. in 1898.


In 1899 he was appointed assistant professor at West Virginia University. He moved to the McLean Hospital Boston in 1900 as a research biochemist, eventually moving to Harvard Medical School in 1907 as an associate professor of biological chemistry, becoming the Hamilton Kuhn professor in 1909.

Together with Vintilă Ciocâlteu Otto Folin designed the Folin-Ciocalteu reagent to detect polyphenols. In 1920, he co-developed with Hsien Wu the Folin-Wu method of assaying glucose in protein-free filtrates of blood.[1][2]

Selected works

  • Approximately complete analyses of thirty "normal" urines (1905)
  • Chemical problems in hospital practice (1908)
  • Nitrogen retention in the blood in experimental acute nephritis in the cat (1912)
  • Preservatives and other chemicals in foods: Their use and abuse (1914)
  • Recent biochemical investigations on blood and urine;: Their bearing on clinical and experimental medicine (1917)
  • Laboratory Manual of Biological Chemistry with Supplement (1925)


  1. ^ Otto Folin's Decade in Minnesota 1882-1892 A Brief Review (Meites, Samuel. Clinical Chemistry, volume 28, issue 10, pages 2173–2177. 1982)Clinical chemistry, Vol 28, No 10, 1982 [1]
  2. ^ Analytical Biochemistry: the Work of Otto Knuf Olof Folin on Blood Analysis(American Society for Biochemistry and Molecular Biology ) [2]

Other sources

  • Schaffer, Phillip Otto Folin: (1867–1934) (Journal of Nutrition. volume 52, issue 1, pages 3–11. 1954) [3]
  • Schaffer, Phillip Otto Folin: (1867–1934) (National Academy Biographical Memoirs,volume 27. 1952 [4]
  • Edsall, John T. A Biomedical Pioneer: Otto Folin (Science 12 May 1989:Vol. 244. no. 4905, pp. 719 - 720) [5]

Related Reading

  • Meites, Samuel Otto Folin, America's First Clinical Biochemist ( American Association for Clinical Chemistry, Inc., Washington, D.C, 1989)

External links

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Look at other dictionaries:

  • Otto Folin — Otto Knut Olof Folin (* 4. April 1867 in Åseda; † 25. Oktober 1934) war ein schwedisch US amerikanischer Pionier der klinischen Biochemie. Leben In Schweden als jüngster von zwölf Söhnen und einer Tochter einer Familie mit kleinem Landbesitz in… …   Deutsch Wikipedia

  • Folin — may refer to : * Otto Folin (1867–1934), a Swedish born American chemist * Folin s reagent, a reagent to detect level of amines in amino acids * Haut Folin, the highest point in the region of Burgundy on France * Léopold de Folin (1817 1896), a… …   Wikipedia

  • Folin — ist der Name folgender Personen: Léopold de Folin (1817–1896), französischer Marineoffizier, Ozeanograph, Zoologe und insbesondere Malakologe Otto Folin (1867–1934), schwedischer Hochschullehrer Diese Seite ist eine Begriffsklärung …   Deutsch Wikipedia

  • Folin-Ciocalteu reagent — The Folin Ciocalteu reagent (FCR) or Folin s phenol reagent or Folin Denis reagent is a mixture of phosphomolybdate and phosphotungstate used for the colorimetric assay of phenolic antioxidants and polyphenolic antioxidants. [Singleton VL,… …   Wikipedia

  • Folin-Ciocalteu-Reagenz — Artikel eintr …   Deutsch Wikipedia

  • Folin — Cette page d’homonymie répertorie les différents sujets et articles partageant un même nom. Folin est un nom de famille : Léopold de Folin (1817 1896), océanographe et malacologiste français Sébastien Folin, présentateur de télévision… …   Wikipédia en Français

  • Folin — Otto K.O., U.S. biochemist, 1867–1934. See F. reaction, F. test, F. Looney test …   Medical dictionary

  • Folin method — Fol·in method (folґin) [Otto Knut Olof Folin, American physiologic chemist, 1867–1934] see under method …   Medical dictionary

  • Reactivo de Folin-Ciocalteu — Saltar a navegación, búsqueda El reactivo de Folin Ciocalteu (FCR) o reactivo de Folin Denis es una mezcla de fosfomolibdato y fosfotungstato, usado para la determinación de antioxidantes fenólicos y polifenólicos.[1] Funciona midiendo la… …   Wikipedia Español

  • James B. Sumner — Infobox Scientist name = James B. Sumner image width = | image size = 180px caption = James B. Sumner birth date = birth date|1887|11|19 birth place = Canton, Massachusetts, USA death date = death date and age|1955|8|12|1887|11|19 death place =… …   Wikipedia

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