IUPAC_name = 7-methoxy-6- [3- [4-(2-methoxyphenyl)piperazin-1-yl] propoxy] -3,4-dimethylchromen-2-one

width= 240
CAS_number= 155773-59-4
PubChem= 208923
C=26 | H=32 | N=2 | O=5
molecular_weight = 452.543
smiles = CC1=C(C(=O)OC2=CC(=C(C=C12)OCCCN3CCN(CC3)C4=CC=CC=C4OC)OC)C
metabolism =
elimination_half-life= 13.7 hours
excretion =
pregnancy_category =
legal_status =

Ensaculin (KA-672) is a drug from the coumarin family, which has been researched as a potential treatment for dementia. It acts on a number of receptor systems, being both a weak NMDA antagonist and a 5HT1A agonist. [Lishko PV, Maximyuk OP, Chatterjee SS, Nöldner M, Krishtal OA. The putative cognitive enhancer KA-672.HCl is an uncompetitive voltage-dependent NMDA receptor antagonist. "Neuroreport". 1998 Dec 21;9(18):4193-7. PMID 9926872] [Winter JC, Helsley SE, Rabin RA. The discriminative stimulus effects of KA 672, a putative cognitive enhancer: evidence for a 5-HT1A component. "Pharmacology, Biochemistry and Behaviour". 1998 Jul;60(3):703-7. PMID 9678654] Animal studies have shown promising nootropic effects, [Hoerr R, Noeldner M. Ensaculin (KA-672 HCl): a multitransmitter approach to dementia treatment. "CNS Drug Reviews". 2002 Summer;8(2):143-58. PMID 12177685] [Knauber J, Müller WE. Anseculin improves passive avoidance learning of aged mice. "Pharmacological Research". 2003 Mar;47(3):225-33. PMID 12591018] although efficacy in humans has yet to be proven. It was well tolerated in human trials, with the main side effect being othostatic hypotension (low blood pressure). [Sourgens H, Hoerr R, Biber A, Steinbrede H, Derendorf H. KA 672-HCl, a neuronal activator against dementia: tolerability, safety, and preliminary pharmacokinetics after single and multiple oral doses in healthy male and female volunteers. "Journal of Clinical Pharmacology". 1998 Apr;38(4):373-81. PMID 9590466]


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Meclofenoxate — Systematic (IUPAC) name 2 Dimethylaminoethyl (4 chlorophenoxy)acetate Clinical data AHFS/Drugs.com …   Wikipedia

  • Coumarin — Not to be confused with coumadin or dicoumarol. This article is about the sweet smelling plant substance called coumarin. For the anticoagulant rodenticide poisons often called coumarins or coumadins , see 4 hydroxycoumarins. Coumarin …   Wikipedia

  • Galantamine — Systematic (IUPAC) name (4aS,6R,8aS) 5,6,9,10,11,12 hexahydro 3 methoxy 11 methyl 4aH [1]benzofuro[3a,3,2 ef] [2] benzazepin 6 ol Clinical data …   Wikipedia

  • Acetylcholinesterase inhibitor — Acetylcholine …   Wikipedia

  • Nicotinic agonist — A nicotinic agonist is a drug which enhances the action at the nicotinic acetylcholine receptor (nAChR). Examples include: nicotine (by definition the nicotinic acetylcholine receptor is named for its affinity for nicotine) acetylcholine, the… …   Wikipedia

  • Cyprodenate — Systematic (IUPAC) name 2 dimethylaminoethyl 3 cyclohexylpropanoate Clinical data AHFS/Drugs.com …   Wikipedia

  • Neramexane — Systematic (IUPAC) name 1,3,3,5,5 pentamethylcyclohexanamine Clinical data Pregnancy cat.  ? …   Wikipedia

  • Cerlapirdine — Systematic (IUPAC) name N,N dimethyl 3 {[3 (naphthalen 1 ylsulfonyl) 2H indazol 5 yl]oxy}propan 1 amine Clinical data Pregnancy cat …   Wikipedia

  • Latrepirdine — Systematic (IUPAC) name 2,3,4,5 tetrahydro 2,8 dimethyl 5 (2 (6 methyl 3 pyridyl)ethyl) 1H pyrido(4,3 b)indole Clinical data Pregnancy cat …   Wikipedia

  • Milameline — Systematic (IUPAC) name (E) N methoxy 1 (1 methyl 1,2,5,6 tetrahydropyridin 3 yl)methanimine Clinical data Pregnancy cat …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.