Cutaneous T cell lymphoma
Name = Cutaneous T cell lymphoma
ICD10 = ICD10|C|84|0|c|81, ICD10|C|84|1|c|81
ICD9 = ICD9|202.1, ICD9|202.2
ICDO = ICDO|9700|3, ICDO|9701|3
eMedicineSubj = med
eMedicineTopic = 3486
DiseasesDB = 8595
MeshID = D016410
Cutaneous T-Cell lymphoma (CTCL) is a class of
non-Hodgkin's lymphoma, which is a type of cancerof the immune system. Unlike most non-Hodgkin's lymphomas (which are generally B-cell related), CTCL is caused by a mutation of T cells. The malignantT cells in the body are pushed to the surface of the skinin a biological process used to rid the body of offending material, causing various lesions to appear on the skin. These lesions change shape as the disease progresses, typically beginning as what appears to be a rashand eventually forming plaques and tumors before metastasizing to other parts of the body.
Though there are many types of CTCL and presentation can vary from individual to individual, there are two main forms:
There is some dispute over whether SS is an advanced form of MF or a different type of CTCL entirely - in either case, the prognosis for SS patients is substantially poorer than for those of MF.
There is no cure for CTCL, but there are a variety of treatment options available and some CTCL patients are able to live somewhat normal lives with this cancer, although symptoms can be debilitating and painful, even in earlier stages.
Treatments include: Topical Corticosteroids, Bexarotene Gel, Carmustine(Nitrogen Mustard), Mechlorethamine, Phototherapy (Broad & Narrow Band UVB or PUVA), Local & Total Skin Electron Beam Radiation, Conventional Radiation Therapy, Oral Corticosteroids, Bexarotene (Targretin) Capsules, Photopheresis, Interferons, Denileukin Diftitox (Ontak), Alemtuzumab (Campath-1H), Vorinostat (Zolinza), Methotrexate, Pentostatin & other purine analogues (Fludarabine, 2- deoxychloroadenosine), Liposomal doxorubicin (Doxil), Gemcitabine (Gemzar), Cyclophosphamide, oral, Bone marrow/Stem cell, and Allogenic Transplantation.
Of all cancers involving the same class of blood cell, 2% of cases are cutaneous T cell lymphomas.cite book
author=Turgeon, Mary Louise
title=Clinical hematology: theory and procedures
publisher=Lippincott Williams & Wilkins
quote=Frequency of lymphoid neoplasms. (Source: Modified from WHO Blue Book on Tumour of Hematopoietic and Lymphoid Tissues. 2001, p. 2001.)]
Anaplastic large cell lymphoma
* [http://www.lymphomainfo.net/nhl/types/ctcl-mf.html Cutaneous T-Cell Lymphomas - The lymphoma Information Network]
* [http://www.clfoundation.org/ The Cutaneous Lymphoma Foundation]
* [http://www.lymphoma.org/ Lymphoma Research Foundation]
* [http://www.moffitt.usf.edu/pubs/ccj/v5n1/article1.html Cutaneous T-cell Lymphoma] -
H. Lee Moffitt Cancer Center & Research Institute
* [http://uuhsc.utah.edu/healthinfo/adult/skin/cuttcell.htm UUHSC]
* [http://www.clinicaltrials.gov/ct/show/NCT00106431 NCI Clinical Trial using Depsipeptide to treat CTCL]
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stage III cutaneous T-cell lymphoma — Nearly all of the skin is red, dry, and scaly; lymph nodes are either normal or enlarged but do not contain cancer cells … English dictionary of cancer terms
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