Cutaneous T cell lymphoma

DiseaseDisorder infobox
Name = Cutaneous T cell lymphoma
ICD10 = ICD10|C|84|0|c|81, ICD10|C|84|1|c|81
ICD9 = ICD9|202.1, ICD9|202.2
ICDO = ICDO|9700|3, ICDO|9701|3


Caption =
OMIM =
MedlinePlus =
eMedicineSubj = med
eMedicineTopic = 3486
DiseasesDB = 8595
MeshID = D016410

Cutaneous T-Cell lymphoma (CTCL) is a class of non-Hodgkin's lymphoma, which is a type of cancer of the immune system. Unlike most non-Hodgkin's lymphomas (which are generally B-cell related), CTCL is caused by a mutation of T cells. The malignant T cells in the body are pushed to the surface of the skin in a biological process used to rid the body of offending material, causing various lesions to appear on the skin. These lesions change shape as the disease progresses, typically beginning as what appears to be a rash and eventually forming plaques and tumors before metastasizing to other parts of the body.

Types

Though there are many types of CTCL and presentation can vary from individual to individual, there are two main forms:

* mycosis fungoides (MF)
* Sézary syndrome (SS)

There is some dispute over whether SS is an advanced form of MF or a different type of CTCL entirely - in either case, the prognosis for SS patients is substantially poorer than for those of MF.

Treatment

There is no cure for CTCL, but there are a variety of treatment options available and some CTCL patients are able to live somewhat normal lives with this cancer, although symptoms can be debilitating and painful, even in earlier stages.

Treatments include: Topical Corticosteroids, Bexarotene Gel, Carmustine(Nitrogen Mustard), Mechlorethamine, Phototherapy (Broad & Narrow Band UVB or PUVA), Local & Total Skin Electron Beam Radiation, Conventional Radiation Therapy, Oral Corticosteroids, Bexarotene (Targretin) Capsules, Photopheresis, Interferons, Denileukin Diftitox (Ontak), Alemtuzumab (Campath-1H), Vorinostat (Zolinza), Methotrexate, Pentostatin & other purine analogues (Fludarabine, 2- deoxychloroadenosine), Liposomal doxorubicin (Doxil), Gemcitabine (Gemzar), Cyclophosphamide, oral, Bone marrow/Stem cell, and Allogenic Transplantation.

Epidemiology

Of all cancers involving the same class of blood cell, 2% of cases are cutaneous T cell lymphomas.cite book
author=Turgeon, Mary Louise
title=Clinical hematology: theory and procedures
publisher=Lippincott Williams & Wilkins
location=Hagerstown, MD
year=2005
pages=283
isbn=0-7817-5007-5
quote=Frequency of lymphoid neoplasms. (Source: Modified from WHO Blue Book on Tumour of Hematopoietic and Lymphoid Tissues. 2001, p. 2001.)
]

References

ee also

* Anaplastic large cell lymphoma

External links

* [http://www.lymphomainfo.net/nhl/types/ctcl-mf.html Cutaneous T-Cell Lymphomas - The lymphoma Information Network]
* [http://www.clfoundation.org/ The Cutaneous Lymphoma Foundation]
*
* [http://www.lymphoma.org/ Lymphoma Research Foundation]
* [http://www.moffitt.usf.edu/pubs/ccj/v5n1/article1.html Cutaneous T-cell Lymphoma] - H. Lee Moffitt Cancer Center & Research Institute
* [http://uuhsc.utah.edu/healthinfo/adult/skin/cuttcell.htm UUHSC]
* [http://www.clinicaltrials.gov/ct/show/NCT00106431 NCI Clinical Trial using Depsipeptide to treat CTCL]


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Cutaneous B-cell lymphoma — Cutaneous B cell lymphomas constitute a group of diseases that occur less commonly than cutaneous T cell lymphoma, and are characterized histologically by B cells that appear similar to those normally found in germinal centers of lymph… …   Wikipedia

  • cutaneous T-cell lymphoma — n any of several lymphomas (as mycosis fungoides or Sezary syndrome) that are marked by clusters of malignant helper T cells in the epidermis causing skin lesions and eruptions which typically progress to tumors and may spread to lymph nodes and… …   Medical dictionary

  • Cutaneous T-cell lymphoma — CTCL redirects here. For the book by Loren Pope, see Colleges That Change Lives. Cutaneous T cell lymphoma Classification and external resources Micrograph showing cutaneous T cell lymphoma …   Wikipedia

  • cutaneous T-cell lymphoma — A disease in which certain cells of the lymph system (called T lymphocytes) become cancerous (malignant) and affect the skin …   English dictionary of cancer terms

  • stage II cutaneous T-cell lymphoma — may be either of the following: (1) stage IIA, in which the skin has red, dry, scaly patches but no tumors, and lymph nodes are enlarged but do not contain cancer cells; (2) stage IIB, in which tumors are found on the skin, and lymph nodes are… …   English dictionary of cancer terms

  • stage IV cutaneous T-cell lymphoma — may be either of the following: in stage IVA cancer, the skin is red, dry, and scaly, and the lymph nodes contain cancer cells; in stage IVB cancer, the skin is red, dry and scaly, cancer cells may be found in lymph nodes, and cancer has spread… …   English dictionary of cancer terms

  • stage I cutaneous T-cell lymphoma — May be either of the following: (1) stage IA cancer affecting less than 10% of the skin s surface and appearing as red, dry, scaly patches; (2) stage IB cancer affecting 10% or more of the skin s surface and appearing as red, dry, scaly patches …   English dictionary of cancer terms

  • stage III cutaneous T-cell lymphoma — Nearly all of the skin is red, dry, and scaly; lymph nodes are either normal or enlarged but do not contain cancer cells …   English dictionary of cancer terms

  • Anaplastic large cell lymphoma — DiseaseDisorder infobox Name = PAGENAME ICD10 = ICD9 = ICDO = ICDO|9714|3 Caption = OMIM = MedlinePlus = eMedicineSubj = derm eMedicineTopic = 534 DiseasesDB = MeshID = D017728 Anaplastic large cell lymphoma (ALCL) is a type of non Hodgkin… …   Wikipedia

  • Mantle cell lymphoma — Classification and external resources Micrograph showing mantle cell lymphoma (bottom of image) in a biopsy of the terminal ileum. H E stain …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.