Selective Relaxant Binding Agent
Selective Relaxant Binding Agents (SRBAs) are a new class of
drugs that selectively encapsulates and binds neuromuscular blocking agents (NMBAs). The first drug introduction of an SRBA is sugammadex. Sugammadex is a modified gamma cyclodextrin that specifically encapsulates and binds the aminosteroid NMBAs: rocuronium> vecuronium>> pancuronium. SRBAs exert a chelatingaction that effectively terminates an NMBA ability to bind to nicotinic receptors.
Discovery of SRBAs
The discovery of SRBA as a new class of drug is the result of work done at Organon laboratories in
Scotland. Cyclodextrins were explored as a means to solubilize rocuronium bromide (a steroidalNMBA) in a neutral aqueous solution. Upon creating numerous modified cyclodextrins, one particular moleculewas found to possess extremely high affinity for the rocuronium molecule. Originally known as Org25969, it is now generically named sugammadex sodium.
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