Methoxamine

Methoxamine
Systematic (IUPAC) name
2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 390-28-3 YesY
ATC code C01CA10
PubChem CID 6082
IUPHAR ligand 483
DrugBank DB00723
ChemSpider 5857 YesY
UNII HUQ1KC1YLI YesY
KEGG D08201 YesY
ChEMBL CHEMBL524 YesY
Chemical data
Formula C11H17NO3 
Mol. mass 211.258
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Methoxamine is an α1-adrenergic receptor agonist,[1] similar in structure to phenylephrine and 2,5-DMA. It was Developed by Burroughs-Wellcome in the 1940s.[2] The drug induces vasoconstriction of skin and splanchnic blood vessels, thereby increasing peripheral vascular resistance and raising mean arterial blood pressure. Because of its hypertensive effects, it may evoke a compensatory reflex bradycardia via the baroreceptors.

See also

References

  1. ^ Pazdernik, Thomas L.; Kerecsen, Laszlo (2007) [2003] "5" in Goljan, Edward F. (Paperback) Pharmacology Rapid Review (Second ed.) Philadelphia, PA: Mosby-Elsevier p. 39 ISBN 9780323045506 
  2. ^ US Patent 2359707 - DIMETHOXYPHENYL beta-HYDROXY ISOPROPYLAMINE