Ibopamine


Ibopamine

drugbox
IUPAC_name = 4-(2-(methylamino)ethyl)-1,2-phenylene bis(2-methylpropanoate)


CAS_number = 66195-31-1
ATC_prefix = C01
ATC_suffix = CA16
ATC_supplemental = ATC|S01|FB03
PubChem = 68555
DrugBank =
C=17|H=25|N=1|O=4
molecular_weight = 307.385 g/mol
bioavailability =
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Ibopamine is a sympathomimetic used in ophthalmology.cite journal |author=Magacho L, Costa ML, Dessimoni A, de Avila MP |title=Comparison between the 1% and 2% ibopamine provocative test in primary open-angle glaucoma patients: sensitivity, specificity and tolerability |journal=Arq Bras Oftalmol |volume=69 |issue=5 |pages=695–9 |year=2006 |pmid=17187138 |doi= |url=http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492006000500015&lng=en&nrm=iso&tlng=en]

It induces mydriasis.cite journal |author=Marchini G, Babighian S, Tosi R, Perfetti S, Bonomi L |title=Effects of 2% ibopamine on pupil, refraction, anterior segment anatomy and intraocular pressure |journal=J Ocul Pharmacol Ther |volume=17 |issue=3 |pages=215–23 |year=2001 |month=June |pmid=11436942 |doi=10.1089/108076801750295254 |url=http://dx.doi.org/10.1089/108076801750295254]

It also has been investigated for use in the treatment of congestive heart failure.cite journal |author=van Veldhuisen DJ, Man in 't Veld AJ, Dunselman PH, "et al" |title=Double-blind placebo-controlled study of ibopamine and digoxin in patients with mild to moderate heart failure: results of the Dutch Ibopamine Multicenter Trial (DIMT) |journal=J. Am. Coll. Cardiol. |volume=22 |issue=6 |pages=1564–73 |year=1993 |month=November |pmid=7901256 |doi= |url=]

It acts on dopaminergic receptors.cite journal |author=Metra M, Missale C, Spano PF, Cas LD |title=Dopaminergic drugs in congestive heart failure: hemodynamic and neuroendocrine responses to ibopamine, dopamine, and dihydroergotoxine |journal=J. Cardiovasc. Pharmacol. |volume=25 |issue=5 |pages=732–40 |year=1995 |month=May |pmid=7630152 |doi= |url=] cite journal |author=Lieverse AG, Girbes AR, Van Veldhuisen DJ, "et al" |title=The effects of ibopamine on glomerular filtration rate and plasma norepinephrine remain preserved during prolonged treatment in patients with congestive heart failure |journal=Eur. Heart J. |volume=16 |issue=7 |pages=937–42 |year=1995 |month=July |pmid=7498209 |doi= |url=http://eurheartj.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=7498209]

It also acts upon adrenergic receptors.cite web |url=http://www.ingentaconnect.com/content/ben/cdth/2007/00000002/00000002/art00006 |title=IngentaConnect Ibopamine Stimulates -Adrenergic Receptors and D1 Dopaminergic Re... |format= |work= |accessdate=]

ee also

* Epinine

References


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