Anti-p62 antibodies

AutoAbBox
Autoantigen = p62
OneIsoform = Yes
OneIsoformSpecialName = Nucleoporin 62kDA
OneGene = NUP62
OneOrgan = Bile Duct
OneTissue =
OneCell =
OneAlso =
OneDisease = Primary biliary cirrhosis
OneIgClass =
OneIgGSubclass =
OneHLA1 = DR2 (weak)
OneHLA2 =
OneHLA3 =
OneAssociatedGene =
OneTCellRestr =
OneTrigger =

Anti-p62 antibodies (AP62A) are found in a primary biliary cirrhosis.cite journal |author=Wesierska-Gadek J, Hohenuer H, Hitchman E, Penner E |title=Autoantibodies against nucleoporin p62 constitute a novel marker of primary biliary cirrhosis |journal=Gastroenterology |volume=110 |issue=3 |pages=840–7 |year=1996 |pmid=8608894 |doi= |issn=] p62 is also more frequent in Stage IV primary biliary cirrhosis and is prognostic for severe disease.cite journal | author = Miyachi K, Hankins RW, Matsushima H, "et al" | title = Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study | journal = J. Autoimmun. | volume = 20 | issue = 3 | pages = 247–54 | year = 2003 | pmid = 12753810 | doi = ] cite journal |author=Invernizzi P, Selmi C, Ranftler C, Podda M, Wesierska-Gadek J |title=Antinuclear antibodies in primary biliary cirrhosis |journal=Semin. Liver Dis. |volume=25 |issue=3 |pages=298–310 |year=2005 |pmid=16143945 |doi=10.1055/s-2005-916321 |issn=] The autoantigen is the nucleoporin 62kDA protein.

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