Transcription Factor II B

Transcription Factor II B (TFIIB) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.cite book | author = Lewin, Benjamin | title = Genes VIII | publisher = Pearson Prentice Hall | location = Upper Saddle River, NJ | year = 2004 | pages = p636-637 | isbn = 0-13-144946-X | oclc = | doi = ] It is encoded by the gene|TFIIB gene.cite journal | author = Ha I, Lane WS, Reinberg D | title = Cloning of a human gene encoding the general transcription initiation factor IIB | journal = Nature | volume = 352 | issue = 6337 | pages = 689–95 | year = 1991 | pmid = 1876184 | doi = 10.1038/352689a0 | issn = ] cite journal | author = Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC | title = Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome | journal = Hum. Mol. Genet. | volume = 3 | issue = 1 | pages = 61–4 | year = 1994 | pmid = 8162052 | doi = 10.1093/hmg/3.1.61 | issn = ]

Transcription factor IIB localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. The protein serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [cite web | title = Entrez Gene: GTF2B general transcription factor IIB| url =| accessdate = ] It is involved in the selection of the transcription start site: mutations in TFIIB cause a shift in the transcription start site.cite journal | author = Lee TI, Young RA | title = Transcription of eukaryotic protein-coding genes | journal = Annu. Rev. Genet. | volume = 34 | issue = | pages = 77–137 | year = 2000 | pmid = 11092823 | doi = 10.1146/annurev.genet.34.1.77]

See also



Further reading

citations =
*cite journal | author=Roeder RG |title=The role of general initiation factors in transcription by RNA polymerase II. |journal=Trends Biochem. Sci. |volume=21 |issue= 9 |pages= 327–35 |year= 1996 |pmid= 8870495 |doi=
*cite journal | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193–205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789
*cite journal | author=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue= |pages= 153–67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013
*cite journal | author=Seelamgari A, Maddukuri A, Berro R, "et al." |title=Role of viral regulatory and accessory proteins in HIV-1 replication. |journal=Front. Biosci. |volume=9 |issue= |pages= 2388–413 |year= 2006 |pmid= 15353294 |doi=
*cite journal | author=Ing NH, Beekman JM, Tsai SY, "et al." |title=Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II). |journal=J. Biol. Chem. |volume=267 |issue= 25 |pages= 17617–23 |year= 1992 |pmid= 1517211 |doi=
*cite journal | author=Malik S, Hisatake K, Sumimoto H, "et al." |title=Sequence of general transcription factor TFIIB and relationships to other initiation factors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 21 |pages= 9553–7 |year= 1991 |pmid= 1946368 |doi=
*cite journal | author=Klemm RD, Goodrich JA, Zhou S, Tjian R |title=Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 13 |pages= 5788–92 |year= 1995 |pmid= 7597030 |doi=
*cite journal | author=Veschambre P, Simard P, Jalinot P |title=Evidence for functional interaction between the HIV-1 Tat transactivator and the TATA box binding protein in vivo. |journal=J. Mol. Biol. |volume=250 |issue= 2 |pages= 169–80 |year= 1995 |pmid= 7608968 |doi= 10.1006/jmbi.1995.0368
*cite journal | author=Desai-Yajnik V, Hadzic E, Modlinger P, "et al." |title=Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivator. |journal=J. Virol. |volume=69 |issue= 8 |pages= 5103–12 |year= 1995 |pmid= 7609079 |doi=
*cite journal | author=Cavaillès V, Dauvois S, L'Horset F, "et al." |title=Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. |journal=EMBO J. |volume=14 |issue= 15 |pages= 3741–51 |year= 1995 |pmid= 7641693 |doi=
*cite journal | author=Nakshatri H, Nakshatri P, Currie RA |title=Interaction of Oct-1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter. |journal=J. Biol. Chem. |volume=270 |issue= 33 |pages= 19613–23 |year= 1995 |pmid= 7642649 |doi=
*cite journal | author=Abendroth FD, Peterson SR, Galman M, "et al." |title=Identification of human autoantibodies to transcription factor IIB. |journal=Nucleic Acids Res. |volume=23 |issue= 14 |pages= 2770–4 |year= 1995 |pmid= 7651839 |doi=
*cite journal | author=Bagby S, Kim S, Maldonado E, "et al." |title=Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein. |journal=Cell |volume=82 |issue= 5 |pages= 857–67 |year= 1995 |pmid= 7671313 |doi=
*cite journal | author=Nikolov DB, Chen H, Halay ED, "et al." |title=Crystal structure of a TFIIB-TBP-TATA-element ternary complex. |journal=Nature |volume=377 |issue= 6545 |pages= 119–28 |year= 1995 |pmid= 7675079 |doi= 10.1038/377119a0
*cite journal | author=Schmitz ML, Stelzer G, Altmann H, "et al." |title=Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor IIB, and coactivators. |journal=J. Biol. Chem. |volume=270 |issue= 13 |pages= 7219–26 |year= 1995 |pmid= 7706261 |doi=
*cite journal | author=Yu L, Zhang Z, Loewenstein PM, "et al." |title=Molecular cloning and characterization of a cellular protein that interacts with the human immunodeficiency virus type 1 Tat transactivator and encodes a strong transcriptional activation domain. |journal=J. Virol. |volume=69 |issue= 5 |pages= 3007–16 |year= 1995 |pmid= 7707527 |doi=
*cite journal | author=Yu L, Loewenstein PM, Zhang Z, Green M |title=In vitro interaction of the human immunodeficiency virus type 1 Tat transactivator and the general transcription factor TFIIB with the cellular protein TAP. |journal=J. Virol. |volume=69 |issue= 5 |pages= 3017–23 |year= 1995 |pmid= 7707528 |doi=
*cite journal | author=Auffray C, Behar G, Bois F, "et al." |title= [

*cite journal | author=Franklin CC, McCulloch AV, Kraft AS |title=In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB. |journal=Biochem. J. |volume=305 ( Pt 3) |issue= |pages= 967–74 |year= 1995 |pmid= 7848298 |doi=

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  • transcription factor — noun Date: 1972 any of various proteins that bind to DNA and play a role in the regulation of gene expression by promoting transcription …   New Collegiate Dictionary

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