name = "Bunyaviridae"
virus_group = v
familia = "Bunyaviridae"
subdivision_ranks = Genus
subdivision = "Hantavirus"

"Bunyaviridae" is a family of negative-stranded RNA viruses. Though generally found in arthropods or rodents, certain viruses in this family occasionally infect humans.

"Bunyaviridae" are vector-borne viruses. With the exception of Hantaviruses, transmission occurs via an arthropod vector (mosquitos, tick, or sandfly). Hantaviruses are transmitted through contact with deer mice feces. Incidence of infection is closely linked to vector activity, for example, mosquito-borne viruses are more common in the summer.

Human infections with certain Bunyaviruses, such as "Crimean-Congo Hemorrhagic Fever virus", are associated with high levels of morbidity and mortality, consequently handling of these viruses must occur with a Biosafety level 4 laboratory.

Hanta virus or Hantavirus Hemorrhagic fever, common in Korea, Scandinavia, Russia, and the American southwest, is associated with high fever, lung edema and pulmonary failure. Mortality is around 55%.

The antibody reaction plays an important role in decreasing levels of virema.

The family "Bunyaviridae" contains the genera:
*Genus "Hantavirus"; type species: "Hantaan virus" (Hantavirus pulmonary syndrome, Korean hemorrhagic fever)
*Genus "Nairovirus"; type species: "Dugbe virus"
*Genus "Orthobunyavirus"; type species: "Bunyamwera virus"
*Genus "Phlebovirus"; type species: "Rift Valley fever virus"
*Genus "Tospovirus"; type species: "Tomato spotted wilt virus"

Of these genera, all infect vertebrates except Tospoviruses, which only infect arthropods and plants.


Bunyavirus morphology is somewhat similar to that of the "Paramyxoviridae" family; Bunyaviruses form enveloped, spherical virions with diameters of 90-100 nm. These viruses contain no matrix proteins.


Bunyaviruses have tripartite genomes consisting of a large (L), medium (M), and small (S) RNA segment. These RNA segments are single-stranded, and exist in a helical formation within the virion. Besides, they exhibit a pseudo-circular structure due to each segment's complementary ends. The L segment encodes the RNA Dependent RNA-polymerase, necessary for viral RNA replication and mRNA synthesis. The M segment encodes the viral glycoproteins, which project from the viral surface and aid the virus in attaching to and entering the host cell. The S segment encodes the nucleocapsid protein (N).

The L and M segment are negative sense. For the Genera of "Phlebovirus" and "Tospovirus", the S segment is ambisense. Ambisense means that some of the genes on the RNA strand are negative sense. The S segment codes for the viral nucleoprotein (N) in the negative sense and a nonstructural (NSs) protein in ambisense.

Total genome size ranges from 11-19 kbp.Fact|date=September 2008


This ambisense arrangement requires two rounds of transcription to be carried out. First the negative sense RNA is transcribed to produce mRNA and a full length replicative intermediate. From this intermediate a subgenomic mRNA encoding the small segment nonstructural protein is produced while the polymerase produced following the first round of transcription can now replicate the full lengh of RNA to produce viral genomes.

Bunyavirus RNA replicates in the cytoplasm, while the viral proteins transit through the ER and Golgi apparatus. Mature virions bud from the Golgi apparatus into vesicles which are transported to the cell surface.

External links

* [http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/00.011.htm ICTVdb Index of Viruses - "Bunyaviridae"]
* [http://www.virology.net/Big_Virology/BVRNAbunya.html The Big Picture Book of Viruses: "Bunyaviridae"]

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Bunyaviridae — Rift Valley Fieber Viren in Gewebe Systematik Reich: Viren …   Deutsch Wikipedia

  • Bunyaviridae — Saltar a navegación, búsqueda ? Flavivirdiae Clasificación de los virus Grupo: V (Virus ARN monocatenario negativo) …   Wikipedia Español

  • Bunyaviridae — См. Буньявирусы (Источник: «Словарь терминов микробиологии») …   Словарь микробиологии

  • Bunyaviridae — Bunyaviridés …   Wikipédia en Français

  • Bunyaviridae — Single stranded RNA (ssRNA) enveloped viruses infecting vertebrates and arthropods. Genome consists of negative sense RNA molecules. Virion spherical or oval, 90 100 m m diameter. Some genera contain organisms causing serious disease, eg. viral… …   Dictionary of molecular biology

  • Bunyaviridae — A family of arboviruses composed of more than 200 virus serotypes and containing at least five genera : Bunyavirus, Hantavirus, Phlebovirus, Nairovirus, and Tospovirus. Virions in all genera except Hantavirus replicate in arthropods. Virions are… …   Medical dictionary

  • Bunyaviridae — Familia de virus ARN de vertebrados. Grupo Anopheles A Grupo Anopheles B Grupo Bakau Grupo de la Fiebre Hemorrágica de Crimea Congo Grupo Kaisodi Grupo Maputto Grupo de la Enfermedad de la Cabra de Nairobi Grupo de la Fiebre del Phlebotomus Grupo …   Enciclopedia Universal

  • Bunyaviridae — noun a large family of arboviruses that affect a wide range of hosts (mainly vertebrates and arthropods) • Hypernyms: ↑arbovirus, ↑arborvirus • Member Holonyms: ↑family …   Useful english dictionary

  • Bunyavirus — Bunyaviridae Bunyaviridés …   Wikipédia en Français

  • БУНЬЯВИРУСЫ — (Bunyaviridae), сем. вирусов, состоящее из одноимённого рода и многих др. вирусов, примыкающих к сем. по морфология, и др. свойствам. Б. содержат однонитчатую РНК с 3 линейными сегментами и циркулярной структурой рибонуклеопротеида. Мол. масса… …   Ветеринарный энциклопедический словарь

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.