Protein-bound paclitaxel

Protein-bound paclitaxel is an injectable formulation of paclitaxel, a mitotic inhibitor drug used in the treatment of breast cancer. [cite web |url= http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=507751 |title= Definition of "protein-bound paclitaxel" |publisher= National Cancer Institute Dictionary of Cancer Terms ] In this formulation, paclitaxel is bonded to albumin as a delivery vehicle. It is sold in the United States under the trade name [http://www.abraxane.com Abraxane] by [http://www.abraxisbio.com Abraxis Bioscience] . [cite web |url= http://www.cancer.gov/cancertopics/druginfo/nanoparticlepaclitaxel |title= Paclitaxel Albumin-stabilized Nanoparticle Formulation |publisher= National Cancer Institute Drug Information ]

This treatment was approved by the Food and Drug Administration in January 2005 for cases where cancer did not respond to other chemotherapy or has relapsed. [cite web |url= http://www.cancer.gov/cancertopics/druginfo/fda-nanoparticle-paclitaxel |title= FDA Approval for Nanoparticle Paclitaxel |publisher= National Cancer Institute Drug Information ]

Abraxane is a firstFact|date=February 2008 in its class of drugs using nanoparticle albumin bound (nab) technology platform. [http://www.abraxisbio.com/rnd_platform_nab.htm nab Technology]

References


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