COMT inhibitor

A COMT inhibitor is an enzyme which inhibits the action of catechol-O-methyl transferase. This enzyme is involved in degrading neurotransmitters.

COMT inhibitors are used in the treatment of Parkinson's disease.

An example is entacapone.cite journal |author=Nissinen E, Nissinen H, Larjonmaa H, "et al" |title=The COMT inhibitor, entacapone, reduces levodopa-induced elevations in plasma homocysteine in healthy adult rats |journal=J Neural Transm |volume=112 |issue=9 |pages=1213–21 |year=2005 |month=September |pmid=15614425 |doi=10.1007/s00702-004-0262-4 |url=http://dx.doi.org/10.1007/s00702-004-0262-4]

Another example is tolcapone.cite journal |author=Giakoumaki SG, Roussos P, Bitsios P |title=Improvement of Prepulse Inhibition and Executive Function by the COMT Inhibitor Tolcapone Depends on COMT Val158Met Polymorphism |journal=Neuropsychopharmacology |volume= |issue= |pages= |year=2008 |month=June |pmid=18536698 |doi=10.1038/npp.2008.82 |url=http://dx.doi.org/10.1038/npp.2008.82]

References


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • COMT-Inhibitor — COMT Hemmer kommen in der Therapie des Morbus Parkinson gemeinsam mit Levodopa und Dopamin zum Einsatz. Wirkungsweise Inhibitor der Catechol O Methyltransferase (COMT), eines Enzyms, das gemeinsam mit der Monoaminooxidase (MAO) für den… …   Deutsch Wikipedia

  • COMT-Inhibitoren — COMT Hemmer kommen in der Therapie des Morbus Parkinson gemeinsam mit Levodopa und Dopamin zum Einsatz. Wirkungsweise Inhibitor der Catechol O Methyltransferase (COMT), eines Enzyms, das gemeinsam mit der Monoaminooxidase (MAO) für den… …   Deutsch Wikipedia

  • COMT-Hemmer — kommen in der Therapie des Morbus Parkinson gemeinsam mit Levodopa und Dopamin zum Einsatz. Wirkungsweise Inhibitor der Catechol O Methyltransferase (COMT), eines Enzyms, das gemeinsam mit der Monoaminooxidase (MAO) für den Metabolismus der… …   Deutsch Wikipedia

  • Monoamine oxidase inhibitor — MAOI redirects here. For the Easter Island statues, see Moai. Monoamine oxidase Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. They are particularly effective in treating… …   Wikipedia

  • Norepinephrine-dopamine reuptake inhibitor — Norepinephrine Dopamine …   Wikipedia

  • Aromatic L-amino acid decarboxylase inhibitor — An aromatic L amino acid decarboxylase inhibitor (synonyms: DOPA decarboxylase inhibitor, DDCI and AAADI) is a drug which inhibits the synthesis of dopamine by the enzyme aromatic L amino acid decarboxylase (AAAD, or DOPA decarboxylase, DDC).… …   Wikipedia

  • Serotonin–norepinephrine reuptake inhibitor — Serotonin No …   Wikipedia

  • Dopamine reuptake inhibitor — Dopamine A dopamine reuptake inhibitor (DRI, DARI) is a type of drug that acts as a reuptake inhibitor for the neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT). This in turn leads to increased extracellular… …   Wikipedia

  • Norepinephrine reuptake inhibitor — Norepinephrine …   Wikipedia

  • Phosphodiesterase inhibitor — A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), therefore preventing the inactivation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.