CD63

CD63, also known as Cluster of Differentiation 63, is a human gene.cite web | title = Entrez Gene: CD63 CD63 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=967| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. The use of alternate polyadenylation sites has been found for this gene. Alternative splicing results in multiple transcript variants encoding different proteins.cite web | title = Entrez Gene: CD63 CD63 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=967| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Horejsí V, Vlcek C |title=Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63. |journal=FEBS Lett. |volume=288 |issue= 1-2 |pages= 1–4 |year= 1991 |pmid= 1879540 |doi=
*cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143–51 |year= 2002 |pmid= 11739647 |doi=
*cite journal | author=Wang MX, Earley JJ, Shields JA, Donoso LA |title=An ocular melanoma-associated antigen. Molecular characterization. |journal=Arch. Ophthalmol. |volume=110 |issue= 3 |pages= 399–404 |year= 1992 |pmid= 1339263 |doi=
*cite journal | author=Hotta H, Miyamoto H, Hara I, "et al." |title=Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5'-flanking regulatory sequences. |journal=Biochem. Biophys. Res. Commun. |volume=185 |issue= 1 |pages= 436–42 |year= 1992 |pmid= 1599482 |doi=
*cite journal | author=Metzelaar MJ, Wijngaard PL, Peters PJ, "et al." |title=CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. |journal=J. Biol. Chem. |volume=266 |issue= 5 |pages= 3239–45 |year= 1991 |pmid= 1993697 |doi=
*cite journal | author=Rapp G, Freudenstein J, Klaudiny J, "et al." |title=Characterization of three abundant mRNAs from human ovarian granulosa cells. |journal=DNA Cell Biol. |volume=9 |issue= 7 |pages= 479–85 |year= 1990 |pmid= 2171551 |doi=
*cite journal | author=Hotta H, Takahashi N, Homma M |title=Transcriptional enhancement of the human gene encoding for a melanoma-associated antigen (ME491) in association with malignant transformation. |journal=Jpn. J. Cancer Res. |volume=80 |issue= 12 |pages= 1186–91 |year= 1990 |pmid= 2516848 |doi=
*cite journal | author=Hotta H, Ross AH, Huebner K, "et al." |title=Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression. |journal=Cancer Res. |volume=48 |issue= 11 |pages= 2955–62 |year= 1988 |pmid= 3365686 |doi=
*cite journal | author=Ross AH, Dietzschold B, Jackson DM, "et al." |title=Isolation and amino terminal sequencing of a novel melanoma-associated antigen. |journal=Arch. Biochem. Biophys. |volume=242 |issue= 2 |pages= 540–8 |year= 1985 |pmid= 4062294 |doi=
*cite journal | author=Berditchevski F, Bazzoni G, Hemler ME |title=Specific association of CD63 with the VLA-3 and VLA-6 integrins. |journal=J. Biol. Chem. |volume=270 |issue= 30 |pages= 17784–90 |year= 1995 |pmid= 7629079 |doi=
*cite journal | author=Nishibori M, Cham B, McNicol A, "et al." |title=The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin. |journal=J. Clin. Invest. |volume=91 |issue= 4 |pages= 1775–82 |year= 1993 |pmid= 7682577 |doi=
*cite journal | author=Radford KJ, Thorne RF, Hersey P |title=CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma. |journal=Biochem. Biophys. Res. Commun. |volume=222 |issue= 1 |pages= 13–8 |year= 1996 |pmid= 8630057 |doi= 10.1006/bbrc.1996.0690
*cite journal | author=Gwynn B, Eicher EM, Peters LL |title=Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome. |journal=Genomics |volume=35 |issue= 2 |pages= 389–91 |year= 1996 |pmid= 8661157 |doi= 10.1006/geno.1996.0375
*cite journal | author=Mannion BA, Berditchevski F, Kraeft SK, "et al." |title=Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29). |journal=J. Immunol. |volume=157 |issue= 5 |pages= 2039–47 |year= 1996 |pmid= 8757325 |doi=
*cite journal | author=Skubitz KM, Campbell KD, Iida J, Skubitz AP |title=CD63 associates with tyrosine kinase activity and CD11/CD18, and transmits an activation signal in neutrophils. |journal=J. Immunol. |volume=157 |issue= 8 |pages= 3617–26 |year= 1996 |pmid= 8871662 |doi=
*cite journal | author=Berditchevski F, Tolias KF, Wong K, "et al." |title=A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase. |journal=J. Biol. Chem. |volume=272 |issue= 5 |pages= 2595–8 |year= 1997 |pmid= 9006891 |doi=
*cite journal | author=Sincock PM, Mayrhofer G, Ashman LK |title=Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin. |journal=J. Histochem. Cytochem. |volume=45 |issue= 4 |pages= 515–25 |year= 1997 |pmid= 9111230 |doi=
*cite journal | author=Berditchevski F, Chang S, Bodorova J, Hemler ME |title=Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 29174–80 |year= 1997 |pmid= 9360995 |doi=
*cite journal | author=Tachibana I, Bodorova J, Berditchevski F, "et al." |title=NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 29181–9 |year= 1997 |pmid= 9360996 |doi=

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • CD63 — Молекула CD63 Обозначения Символы CD63; LAMP 3; ME491; MLA1; OMA81H; TSPAN30 Entrez Gene …   Википедия

  • Basophil activation — Allergic symptoms are caused by an initial systemic histamine release by activated basophiles and mast cells, that may lead to shock with laryngeal edema, lower airway obstruction and hypotension. This is why basophiles are considered with mast… …   Wikipedia

  • CD9 — molecule Identifiers Symbols CD9; BTCC 1; DRAP 27; FLJ99568; MIC3; MRP 1; TSPAN 29; TSPAN29 External IDs …   Wikipedia

  • CD53 — CD53, also known as Cluster of Differentiation 53, is a human gene.cite web | title = Entrez Gene: CD53 CD53 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=963| accessdate = ] PBB Summary section… …   Wikipedia

  • Dense granule — Latin granulum delta Code TH H2.00.04.1.03006 Dense granules (also known as dense bodies or delta granules) are specialized secretory organelles …   Wikipedia

  • Tetraspanin — family Tetraspanins have four transmembrane domains, two extracellular loops and contain a series of highly conserved amino acid residues. Identifiers Symbol Tetraspannin …   Wikipedia

  • CD81 — molecule, also known as CD81 (Cluster of Differentiation 81), is a human gene.cite web | title = Entrez Gene: CD81 CD81 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=975| accessdate = ] PBB… …   Wikipedia

  • CD82 (gene) — CD82 (Cluster of Differentiation 82) is a human protein encoded by the gene|CD82 gene.cite web | title = Entrez Gene: CD82 CD82 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=3732| accessdate = ]… …   Wikipedia

  • LAMP3 — Lysosomal associated membrane protein 3 Обозначения Символы LAMP3; CD208, DC LAMP, DCLAMP, LAMP, TSC403 Entrez Gene …   Википедия

  • Cluster of differentiation — The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells, providing targets for immunophenotyping of cells …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.