CD63, also known as Cluster of Differentiation 63, is a human gene.cite web | title = Entrez Gene: CD63 CD63 molecule| url =| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. The use of alternate polyadenylation sites has been found for this gene. Alternative splicing results in multiple transcript variants encoding different proteins.cite web | title = Entrez Gene: CD63 CD63 molecule| url =| accessdate = ]

ee also

* Cluster of differentiation


Further reading

citations =
*cite journal | author=Horejsí V, Vlcek C |title=Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63. |journal=FEBS Lett. |volume=288 |issue= 1-2 |pages= 1–4 |year= 1991 |pmid= 1879540 |doi=
*cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143–51 |year= 2002 |pmid= 11739647 |doi=
*cite journal | author=Wang MX, Earley JJ, Shields JA, Donoso LA |title=An ocular melanoma-associated antigen. Molecular characterization. |journal=Arch. Ophthalmol. |volume=110 |issue= 3 |pages= 399–404 |year= 1992 |pmid= 1339263 |doi=
*cite journal | author=Hotta H, Miyamoto H, Hara I, "et al." |title=Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5'-flanking regulatory sequences. |journal=Biochem. Biophys. Res. Commun. |volume=185 |issue= 1 |pages= 436–42 |year= 1992 |pmid= 1599482 |doi=
*cite journal | author=Metzelaar MJ, Wijngaard PL, Peters PJ, "et al." |title=CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. |journal=J. Biol. Chem. |volume=266 |issue= 5 |pages= 3239–45 |year= 1991 |pmid= 1993697 |doi=
*cite journal | author=Rapp G, Freudenstein J, Klaudiny J, "et al." |title=Characterization of three abundant mRNAs from human ovarian granulosa cells. |journal=DNA Cell Biol. |volume=9 |issue= 7 |pages= 479–85 |year= 1990 |pmid= 2171551 |doi=
*cite journal | author=Hotta H, Takahashi N, Homma M |title=Transcriptional enhancement of the human gene encoding for a melanoma-associated antigen (ME491) in association with malignant transformation. |journal=Jpn. J. Cancer Res. |volume=80 |issue= 12 |pages= 1186–91 |year= 1990 |pmid= 2516848 |doi=
*cite journal | author=Hotta H, Ross AH, Huebner K, "et al." |title=Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression. |journal=Cancer Res. |volume=48 |issue= 11 |pages= 2955–62 |year= 1988 |pmid= 3365686 |doi=
*cite journal | author=Ross AH, Dietzschold B, Jackson DM, "et al." |title=Isolation and amino terminal sequencing of a novel melanoma-associated antigen. |journal=Arch. Biochem. Biophys. |volume=242 |issue= 2 |pages= 540–8 |year= 1985 |pmid= 4062294 |doi=
*cite journal | author=Berditchevski F, Bazzoni G, Hemler ME |title=Specific association of CD63 with the VLA-3 and VLA-6 integrins. |journal=J. Biol. Chem. |volume=270 |issue= 30 |pages= 17784–90 |year= 1995 |pmid= 7629079 |doi=
*cite journal | author=Nishibori M, Cham B, McNicol A, "et al." |title=The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin. |journal=J. Clin. Invest. |volume=91 |issue= 4 |pages= 1775–82 |year= 1993 |pmid= 7682577 |doi=
*cite journal | author=Radford KJ, Thorne RF, Hersey P |title=CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma. |journal=Biochem. Biophys. Res. Commun. |volume=222 |issue= 1 |pages= 13–8 |year= 1996 |pmid= 8630057 |doi= 10.1006/bbrc.1996.0690
*cite journal | author=Gwynn B, Eicher EM, Peters LL |title=Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome. |journal=Genomics |volume=35 |issue= 2 |pages= 389–91 |year= 1996 |pmid= 8661157 |doi= 10.1006/geno.1996.0375
*cite journal | author=Mannion BA, Berditchevski F, Kraeft SK, "et al." |title=Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29). |journal=J. Immunol. |volume=157 |issue= 5 |pages= 2039–47 |year= 1996 |pmid= 8757325 |doi=
*cite journal | author=Skubitz KM, Campbell KD, Iida J, Skubitz AP |title=CD63 associates with tyrosine kinase activity and CD11/CD18, and transmits an activation signal in neutrophils. |journal=J. Immunol. |volume=157 |issue= 8 |pages= 3617–26 |year= 1996 |pmid= 8871662 |doi=
*cite journal | author=Berditchevski F, Tolias KF, Wong K, "et al." |title=A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase. |journal=J. Biol. Chem. |volume=272 |issue= 5 |pages= 2595–8 |year= 1997 |pmid= 9006891 |doi=
*cite journal | author=Sincock PM, Mayrhofer G, Ashman LK |title=Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin. |journal=J. Histochem. Cytochem. |volume=45 |issue= 4 |pages= 515–25 |year= 1997 |pmid= 9111230 |doi=
*cite journal | author=Berditchevski F, Chang S, Bodorova J, Hemler ME |title=Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 29174–80 |year= 1997 |pmid= 9360995 |doi=
*cite journal | author=Tachibana I, Bodorova J, Berditchevski F, "et al." |title=NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 29181–9 |year= 1997 |pmid= 9360996 |doi=

External links


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