Thiopurine


Thiopurine

The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.

ee also

* 6-mercaptopurine (6-MP)
* 6-thioguanine (6-TG)
* Azathioprine (AZA)

References

http://www.pharmgkb.org/do/serve?objId=PA2040


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • thiopurine — noun Any of several types of sulfur derivative of a purine, some of which have medical applications …   Wiktionary

  • thiopurine — thi·o·pu·rine (thi″o puґrēn) 1. a purine base in which a thiol group is found in place of one of the hydroxyl groups. 2. any of a group of drugs that include such a compound as part of their structure …   Medical dictionary

  • Thiopurine methyltransferase — or thiopurine S methyltransferase (TPMT) is an enzyme (EC number|2.1.1.67) that methylates thiopurine compounds. The methyl donor is S adenosyl L methionine, which is converted to S adenosyl L homocysteine.This gene encodes the enzyme that… …   Wikipedia

  • TPMT — thiopurine methyltransferase …   Medical dictionary

  • TPMT — • thiopurine methyltransferase …   Dictionary of medical acronyms & abbreviations

  • Mercaptopurine — Systematic (IUPAC) name 3,7 dihydropurine 6 thione Clinical data Trade names Purinethol …   Wikipedia

  • Pharmacogenetics — The terms pharmacogenomics and pharmacogenetics tend to be used interchangeably, and a precise, consensus definition of either remains elusive. Pharmacogenetics is generally regarded as the study or clinical testing of genetic variation that… …   Wikipedia

  • Thiopurin-Methyltransferase — Bändermodell der TMPT nach PDB 2bzg …   Deutsch Wikipedia

  • Тамм, Риин — Риин Тамм эст. Riin Tamm …   Википедия

  • Methotrexate — Amethopterin redirects here. Not to be confused with aminopterin. Methotrexate Systematic ( …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.