Satraplatin


Satraplatin

Drugbox
IUPAC_name = ("OC"-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum



CAS_number = 129580-63-8
ATC_prefix =
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PubChem = 123974
DrugBank =
C=10|H=22|Cl=2|N=2|O=4|Pt=1
molecular_weight = 500.277 g/mol
synonyms = BMY 45594BMS 182751bis-acetatoamminedichlorocyclohexylamine platinum(IV)
bioavailability =
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routes_of_administration = Oral

Satraplatin (INN, codenamed JM216) is a platinum compound that is currently under investigation as one treatment of patients with advanced prostate cancer who have failed previous chemotherapy. It has not yet received approval from the U.S. Food and Drug Administration. First mentioned in the medical literature in 1993, [cite journal |author=Kelland LR, Abel G, McKeage MJ, "et al" |title=Preclinical antitumor evaluation of bis-acetato-ammine-dichloro-cyclohexylamine platinum(IV): an orally active platinum drug |journal=Cancer Res |volume=53 |issue=11 |pages=2581–6 |year=1993 |pmid=8388318 [http://cancerres.aacrjournals.org/cgi/reprint/53/11/2581.pdf?ijkey=75245aaa945af744674b85b6ae5d36a42c09477d Free full text] ] satraplatin is the first orally active platinum-based chemotherapeutic drug; [cite journal |author=Choy H, Park C, Yao M |title=Current status and future prospects for satraplatin, an oral platinum analogue |journal=Clin Cancer Res |volume=14 |issue=6 |pages=1633–8 |year=2008 |pmid=18347164 |doi=10.1158/1078-0432.CCR-07-2176] other available platinum analogues—cisplatin, carboplatin, and oxaliplatin—must be given intravenously.

It is made available in the United States jointly by Spectrum Pharmaceuticals and GPC Biotech under the name SPERA (Satraplatin Expanded Rapid Access).

The drug has also been used in the treatment of lung and ovarian cancers. The mode of action is that the compound binds to the DNA of cancer cells rendering them incapable of dividing. [ [http://www.spectrumpharm.com/satraplatin.html Satraplatin - Spectrum Pharmaceuticals ] ]

References


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