Eosinophil-derived neurotoxin

Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin), also known as RNASE2, is a human gene.cite web | title = Entrez Gene: RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6036| accessdate = ]

The protein encoded by this gene is found in eosinophil granulocytes.


Further reading

citations =
*cite journal | author=Rosenberg HF, Domachowske JB |title=Eosinophils, ribonucleases and host defense: solving the puzzle. |journal=Immunol. Res. |volume=20 |issue= 3 |pages= 261–74 |year= 2000 |pmid= 10741866 |doi=
*cite journal | author=Abu-Ghazaleh RI, Dunnette SL, Loegering DA, "et al." |title=Eosinophil granule proteins in peripheral blood granulocytes. |journal=J. Leukoc. Biol. |volume=52 |issue= 6 |pages= 611–8 |year= 1993 |pmid= 1464733 |doi=
*cite journal | author=Mastrianni DM, Eddy RL, Rosenberg HF, "et al." |title=Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14. |journal=Genomics |volume=13 |issue= 1 |pages= 240–2 |year= 1992 |pmid= 1577491 |doi=
*cite journal | author=Sakakibara R, Hashida K, Kitahara T, Ishiguro M |title=Characterization of a unique nonsecretory ribonuclease from urine of pregnant women. |journal=J. Biochem. |volume=111 |issue= 3 |pages= 325–30 |year= 1992 |pmid= 1587793 |doi=
*cite journal | author=Hamann KJ, Ten RM, Loegering DA, "et al." |title=Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily. |journal=Genomics |volume=7 |issue= 4 |pages= 535–46 |year= 1990 |pmid= 2387583 |doi=
*cite journal | author=Hamann KJ, Barker RL, Loegering DA, "et al." |title=Sequence of human eosinophil-derived neurotoxin cDNA: identity of deduced amino acid sequence with human nonsecretory ribonucleases. |journal=Gene |volume=83 |issue= 1 |pages= 161–7 |year= 1990 |pmid= 2591744 |doi=
*cite journal | author=Rosenberg HF, Tenen DG, Ackerman SJ |title=Molecular cloning of the human eosinophil-derived neurotoxin: a member of the ribonuclease gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 12 |pages= 4460–4 |year= 1989 |pmid= 2734298 |doi=
*cite journal | author=Barker RL, Loegering DA, Ten RM, "et al." |title=Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases. |journal=J. Immunol. |volume=143 |issue= 3 |pages= 952–5 |year= 1989 |pmid= 2745977 |doi=
*cite journal | author=Beintema JJ, Hofsteenge J, Iwama M, "et al." |title=Amino acid sequence of the nonsecretory ribonuclease of human urine. |journal=Biochemistry |volume=27 |issue= 12 |pages= 4530–8 |year= 1988 |pmid= 3166997 |doi=
*cite journal | author=Sorrentino S, Tucker GK, Glitz DG |title=Purification and characterization of a ribonuclease from human liver. |journal=J. Biol. Chem. |volume=263 |issue= 31 |pages= 16125–31 |year= 1988 |pmid= 3182786 |doi=
*cite journal | author=Gleich GJ, Loegering DA, Bell MP, "et al." |title=Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 10 |pages= 3146–50 |year= 1986 |pmid= 3458170 |doi=
*cite journal | author=Niwata Y, Ohgi K, Sanda A, "et al." |title=Purification and properties of bovine kidney ribonucleases. |journal=J. Biochem. |volume=97 |issue= 3 |pages= 923–34 |year= 1985 |pmid= 3926759 |doi=
*cite journal | author=de Beer T, Vliegenthart JF, Löffler A, Hofsteenge J |title=The hexopyranosyl residue that is C-glycosidically linked to the side chain of tryptophan-7 in human RNase Us is alpha-mannopyranose. |journal=Biochemistry |volume=34 |issue= 37 |pages= 11785–9 |year= 1995 |pmid= 7547911 |doi=
*cite journal | author=Hofsteenge J, Müller DR, de Beer T, "et al." |title=New type of linkage between a carbohydrate and a protein: C-glycosylation of a specific tryptophan residue in human RNase Us. |journal=Biochemistry |volume=33 |issue= 46 |pages= 13524–30 |year= 1994 |pmid= 7947762 |doi=
*cite journal | author=Kardana A, Bagshawe KD, Coles B, "et al." |title=Characterisation of UGP and its relationship with beta-core fragment. |journal=Br. J. Cancer |volume=67 |issue= 4 |pages= 686–92 |year= 1993 |pmid= 8471426 |doi=
*cite journal | author=Mosimann SC, Newton DL, Youle RJ, James MN |title=X-ray crystallographic structure of recombinant eosinophil-derived neurotoxin at 1.83 A resolution. |journal=J. Mol. Biol. |volume=260 |issue= 4 |pages= 540–52 |year= 1996 |pmid= 8759319 |doi= 10.1006/jmbi.1996.0420
*cite journal | author=Krieg J, Hartmann S, Vicentini A, "et al." |title=Recognition signal for C-mannosylation of Trp-7 in RNase 2 consists of sequence Trp-x-x-Trp. |journal=Mol. Biol. Cell |volume=9 |issue= 2 |pages= 301–9 |year= 1998 |pmid= 9450956 |doi=
*cite journal | author=Sur S, Glitz DG, Kita H, "et al." |title=Localization of eosinophil-derived neurotoxin and eosinophil cationic protein in neutrophilic leukocytes. |journal=J. Leukoc. Biol. |volume=63 |issue= 6 |pages= 715–22 |year= 1998 |pmid= 9620664 |doi=
*cite journal | author=Zhang J, Rosenberg HF |title=Sequence variation at two eosinophil-associated ribonuclease loci in humans. |journal=Genetics |volume=156 |issue= 4 |pages= 1949–58 |year= 2001 |pmid= 11102386 |doi=

ee also

* Ribonuclease A

External links


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