Granulocyte macrophage colony-stimulating factor receptor

The granulocyte macrophage colony-stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte macrophage colony-stimulating factor, which stimulates the production of white blood cells. The receptor is normally located on myeloblast, mature neutrophil, but not on any erythroid or megakaryocytic lineage cells.cite journal | author = Nicola NA, Metcalf D | title = Binding of 125I-labeled granulocyte colony-stimulating factor to normal murine hemopoietic cells | journal = J. Cell. Physiol. | volume = 124 | issue = 2 | pages = 313–21 | year = 1985 | pmid = 3876343 | doi = 10.1002/jcp.1041240222 | issn = ]

tructure

The granulocyte macrophage colony-stimulating factor receptor is a heterodimer composed of at least two different subunits; an α chain, and a β chain which is also present in the receptors for IL-3 and IL-5. The α subunit contains a binding site for granulocyte macrophage colony-stimulating factor.cite journal | author = McClure BJ, Hercus TR, Cambareri BA, Woodcock JM, Bagley CJ, Howlett GJ, Lopez AF | title = Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex | journal = Blood | volume = 101 | issue = 4 | pages = 1308–15 | year = 2003 | pmid = 12393492 | doi = 10.1182/blood-2002-06-1903 | issn = ] The β chain is involved in signal transduction. Association of the α and β subunits results in receptor activation.cite journal | author = Geijsen N, Koenderman L, Coffer PJ | title = Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family | journal = Cytokine Growth Factor Rev. | volume = 12 | issue = 1 | pages = 19–25 | year = 2001 | pmid = 11312115 | doi = 10.1016/S1359-6101(00)00019-8 | issn = ]

ignal transduction

Upon dimerisation of the α and β subunits the β subunit becomes phosphorylated on tyrosine residues by members of the Janus kinase (JAK) family. This leads to association with a Shc adaptor protein. Then Shc interacts with GRB2/SoS complex which results in activation of more downstream molecules in the pathway.cite journal | author = Doyle SE, Gasson JC | title = Characterization of the role of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit in the activation of JAK2 and STAT5 | journal = Blood | volume = 92 | issue = 3 | pages = 867–76 | year = 1998 | pmid = 9680354 | doi = | issn = | url = http://bloodjournal.hematologylibrary.org/cgi/content/abstract/bloodjournal;92/3/86 ]

References

Further reading

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citations =
*cite journal | author=Rappold G, Willson TA, Henke A, Gough NM |title=Arrangement and localization of the human GM-CSF receptor alpha chain gene CSF2RA within the X-Y pseudoautosomal region. |journal=Genomics |volume=14 |issue= 2 |pages= 455–61 |year= 1992 |pmid= 1358805 |doi=
*cite journal | author=Hayashida K, Kitamura T, Gorman DM, "et al." |title=Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 24 |pages= 9655–9 |year= 1991 |pmid= 1702217 |doi=
*cite journal | author=Crosier KE, Wong GG, Mathey-Prevot B, "et al." |title=A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 17 |pages= 7744–8 |year= 1991 |pmid= 1715577 |doi=
*cite journal | author=Raines MA, Liu L, Quan SG, "et al." |title=Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 18 |pages= 8203–7 |year= 1991 |pmid= 1832774 |doi=
*cite journal | author=Gough NM, Gearing DP, Nicola NA, "et al." |title=Localization of the human GM-CSF receptor gene to the X-Y pseudoautosomal region. |journal=Nature |volume=345 |issue= 6277 |pages= 734–6 |year= 1990 |pmid= 1972780 |doi= 10.1038/345734a0
*cite journal | author=Ashworth A, Kraft A |title=Cloning of a potentially soluble receptor for human GM-CSF. |journal=Nucleic Acids Res. |volume=18 |issue= 23 |pages= 7178 |year= 1991 |pmid= 2148207 |doi=
*cite journal | author=Gearing DP, King JA, Gough NM, Nicola NA |title=Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. |journal=EMBO J. |volume=8 |issue= 12 |pages= 3667–76 |year= 1990 |pmid= 2555171 |doi=
*cite journal | author=DiPersio J, Billing P, Kaufman S, "et al." |title=Characterization of the human granulocyte-macrophage colony-stimulating factor receptor. |journal=J. Biol. Chem. |volume=263 |issue= 4 |pages= 1834–41 |year= 1988 |pmid= 2828352 |doi=
*cite journal | author=Williams WV, VonFeldt JM, Rosenbaum H, "et al." |title=Molecular cloning of a soluble form of the granulocyte-macrophage colony-stimulating factor receptor alpha chain from a myelomonocytic cell line. Expression, biologic activity, and preliminary analysis of transcript distribution. |journal=Arthritis Rheum. |volume=37 |issue= 10 |pages= 1468–78 |year= 1994 |pmid= 7945472 |doi=
*cite journal | author=Jubinsky PT, Laurie AS, Nathan DG, "et al." |title=Expression and function of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit. |journal=Blood |volume=84 |issue= 12 |pages= 4174–85 |year= 1995 |pmid= 7994031 |doi=
*cite journal | author=Hu X, Emanuel PD, Zuckerman KS |title=Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor. |journal=Biochim. Biophys. Acta |volume=1223 |issue= 2 |pages= 306–8 |year= 1994 |pmid= 8086503 |doi=
*cite journal | author=Nakagawa Y, Kosugi H, Miyajima A, "et al." |title=Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. Implications for the evolution of the cytokine receptor superfamily. |journal=J. Biol. Chem. |volume=269 |issue= 14 |pages= 10905–12 |year= 1994 |pmid= 8144676 |doi=
*cite journal | author=Zhao Y, Rong H, Chegini N |title=Expression and selective cellular localization of granulocyte-macrophage colony-stimulating factor (GM-CSF) and GM-CSF alpha and beta receptor messenger ribonucleic acid and protein in human ovarian tissue. |journal=Biol. Reprod. |volume=53 |issue= 4 |pages= 923–30 |year= 1996 |pmid= 8547489 |doi=
*cite journal | author=Lia F, Rajotte D, Clark SC, Hoang T |title=A dominant negative granulocyte-macrophage colony-stimulating factor receptor alpha chain reveals the multimeric structure of the receptor complex. |journal=J. Biol. Chem. |volume=271 |issue= 45 |pages= 28287–93 |year= 1996 |pmid= 8910448 |doi=
*cite journal | author=Wei S, Liu JH, Epling-Burnette PK, "et al." |title=Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor. |journal=J. Immunol. |volume=157 |issue= 11 |pages= 5155–62 |year= 1996 |pmid= 8943427 |doi=
*cite journal | author=Soldi R, Primo L, Brizzi MF, "et al." |title=Activation of JAK2 in human vascular endothelial cells by granulocyte-macrophage colony-stimulating factor. |journal=Blood |volume=89 |issue= 3 |pages= 863–72 |year= 1997 |pmid= 9028317 |doi=
*cite journal | author=Matsuguchi T, Zhao Y, Lilly MB, Kraft AS |title=The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha subunit is essential for both GM-CSF-mediated growth and differentiation. |journal=J. Biol. Chem. |volume=272 |issue= 28 |pages= 17450–9 |year= 1997 |pmid= 9211889 |doi=
*cite journal | author=Rivas CI, Vera JC, Delgado-López F, "et al." |title=Expression of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer. |journal=Blood |volume=91 |issue= 3 |pages= 1037–43 |year= 1998 |pmid= 9446667 |doi=
*cite journal | author=Hu X, Zuckerman KS |title=Cloning and sequencing of an alternative splicing-derived cDNA variant of the GM-CSF receptor alpha subunit, which encodes a truncated protein. |journal=Am. J. Hematol. |volume=58 |issue= 2 |pages= 145–7 |year= 1998 |pmid= 9625584 |doi=
*cite journal | author=Taha RA, Leung DY, Ghaffar O, "et al." |title=In vivo expression of cytokine receptor mRNA in atopic dermatitis. |journal=J. Allergy Clin. Immunol. |volume=102 |issue= 2 |pages= 245–50 |year= 1998 |pmid= 9723668 |doi=

External links

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