Homoserine lactone

Homoserine lactones are signaling chemicals involved in microbiological quorum sensing.They signal changes in gene expression, such as switching between the flagella gene and the gene for pili for the development of a biofilm.

In the presence of homoserine lactones, the operon "luxAB" is transcribed. These Lux genes are present in the chemiluminescent bacterium "Vibrio fischeri", and similar operons are present in other bioluminescent bacteria. Transcription of the operon results in luminescence due to the expression of LuxA and LuxB, which form a protein known as luciferase.

It is also a product of the proteolytic reaction of cyanogen bromide (CNBR) with a methionine residue in a protein. This reaction is important in protein sequencing, as the Edman degradation process is unable to sequence more than 70 residues at a time.

History:Homoserine lactones were first discovered at Cornell University.


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Homoserine lactone — Homosérine lactone Structure des acyl homosérine lactones Les Homosérine lactones sont des composés chimiques qui, sous forme acylée, sont impliqués dans le quorum sensing chez les bactéries. Différentes formes d acyl homosérine lactones sont… …   Wikipédia en Français

  • Homosérine lactone — Structure des acyl homosérine lactones Les Homosérine lactones sont des composés chimiques qui, sous forme acylée, sont impliqués dans le quorum sensing chez les bactéries. Différentes formes d acyl homosérine lactones sont utilisées par diverses …   Wikipédia en Français

  • N-Acyl homoserine lactone — General chemical structure of an N acyl homoserine lactone N Acyl homoserine lactones (AHLs or N AHLs) are a class of signaling molecules involved in bacterial quorum sensing. Quorum sensing is a method of communication between bacteria that… …   Wikipedia

  • Homoserine — is an α amino acid with the chemical formula HO2CCH(NH2)CH2CH2OH. L Homoserine is not one of the common amino acids encoded by DNA. It differs from the proteinogenic amino acid serine by insertion of an additional methylene group. Homoserine, or… …   Wikipedia

  • homoserine — Amino 4 hydroxybutyric acid; a hydroxyamino acid differing from serine in the possession of an additional CH2 group. An intermediate in the biosynthesis of cystathionine, threonine, and methionine. h. deaminase SYN: cystathionine γ lyase. h.… …   Medical dictionary

  • Lactonase — An enzyme, produced by certain species of bacteria, which targets and inactivates acylated homoserine lactones (AHLs). Many species of the Proteobacteria genus from the alpha, beta and gamma classes have been shown to produce acylated homoserine… …   Wikipedia

  • Hydrolase — Cristal de lysozyme Les hydrolases constituent une classe d enzymes qui catalysent les réactions d hydrolyse de molécules suivant la réaction générale : R R + H2O ⇌ R OH + R H On y trouve par exemple les estérases, qui hydrolysent les …   Wikipédia en Français

  • Erwinia psidii — Taxobox color = lightgrey name = Erwinia psidii regnum = Bacteria phylum = Proteobacteria classis = Gamma Proteobacteria ordo = Enterobacteriales familia = Enterobacteriaceae genus = Erwinia species = E. psidii binomial = Erwinia psidii binomial… …   Wikipedia

  • Cyanogen bromide — Cyanogen bromide …   Wikipedia

  • HSL — may refer to: * Hogesnelheidslijn , a Dutch high speed railway line: HSL Zuid, HSL Oost * High Speed Line , a Belgian high speed railway line: HSL 1, HSL 2, HSL 3, HSL 4 *Heeling Sports Limited, which owns the Heelys and Soap Shoes brands *HSL… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.