Cirazoline

Cirazoline
Identifiers
CAS number 59939-16-1
PubChem 2765
ChemSpider 2663 YesY
MeSH cirazoline
ChEMBL CHEMBL13852 YesY
IUPHAR ligand 515
Jmol-3D images Image 1
Properties
Molecular formula C13H16N2O
Molar mass 216.279
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Cirazoline is a nonselective agonist of the alpha-1 adrenergic receptor (α1-AR), and an antagonist to the alpha-2 adrenergic receptor[1]. It is believed that this combination of properties could make cirazoline an effective vasoconstricting agent[1].

Cirazoline has also been shown to decrease food intake in rats, purportedly through activation of alpha 1-adrenoceptors in the paraventricular nucleus in the hypothalamus of the brain[2].

References

  1. ^ a b Ruffolo Jr, RR; Ruffolo and Waddell (1982). "Receptor interactions of imidazolines. IX. Cirazoline is an alpha-1 adrenergic agonist and an alpha-2 adrenergic antagonist". J Pharmacol Exp Ther. 222 (1): 29–36. PMID 6123592. 
  2. ^ Davies, BT; Davies BT, Wellman PJ (Jan. 1992). "Effects on ingestive behavior in rats of the alpha 1-adrenoceptor agonist cirazoline". Eur J Pharmacol. 210 (1): 11–16. doi:10.1016/0014-2999(92)90645-K. PMID 1350985. 

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