Systematic (IUPAC) name
Clinical data
AHFS/ International Drug Names
Pregnancy cat.  ?
Legal status Veterinary use only
Pharmacokinetic data
Half-life 30mins
CAS number 86347-15-1 YesY
ATCvet code QN05CM90
PubChem CID 56032
ChemSpider 50586 YesY
KEGG D07795 YesY
Chemical data
Formula C12H14N2 
Mol. mass 186.253 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Detomidine is an imidazole derivative and α2-adrenergic agonist, used as a large animal sedative, primarily used in horses. It is usually available as the salt detomidine hydrochloride. It is a prescription medication available to veterinarians sold under the trade name Dormosedan.

Currently, Detomidine is only licenced for use in horses.



Detomidine is a sedative with analgesic properties.[1] α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. Due to inhibition of the sympathetic nervous system, detomidine also has cardiac and respiratory effects and an antidiuretic action.[2]


A profound lethargy and characteristic lowering of the head with reduced sensitivity to environmental stimuli (sound, pain, etc.) are seen with detomidine. A short period of reduced coordination is characteristically followed by immobility and a firm stance with front legs spread. Following administration there is an initial increase in blood pressure, followed by bradycardia and second degree atrioventricular block (this is not pathologic in horses). The horse commonly sweats to excess, especially on the flanks and neck. Other side effects reported include pilo erection (hair standing erect), ataxia, salivation, slight muscle tremors, and (rarely) penile prolapse.


Sedation and anaesthetic premedication in horses and other large animals, commonly combined with butorphanol for increased analgesia and depth of sedation. In conjunction with ketamine it may also be used for intravenous anaesthesia of short duration.

The drug is normally administered by the intravenous route, and is fastest and most efficient when given intravenously . However, in recalcitrant animals, detomidine may be administered by the intramuscular or sublingual routes. The dose range advised by the manufacturers is 20-40 mcg/kg intravenous for moderate sedation, but this dose may need to be higher if given intramuscularly.

When given intravenously, Detomidine usually takes effect in 2–5 minutes, and recovery is full within 30-60 minutes, (however, this is highly dependent upon the dosage, environment, and the individual animal; some horses are highly resistant to sedation!)


As detomidine is an arrhythmogenic agent, extreme care should be exercised in horses with cardiac disease, and in the concurrent administration of other arrhythmogenics. The concurrent use of potentiated sulfonamide antibiotics is considered particularly dangerous.

Detomidine is a poor premedication when using Ketamine as an anesthetic in horses.

Anesthetic recoveries in horses that have received Ketamine following a Detomidine premedication are often violent with the horse having multiple failures to stand resulting in trauma to itself. Xylazine is a superior premedication with Ketamine resulting in safer recoveries.


  1. ^ England GC, Clake KW. α2 adrenoceptor in the horse: a review. (1996). Br Vet J. 152 (6): 641–657. 
  2. ^ Fornai F, Blandizzi C, del Tacca M. (1990). Pharmacol Res. 22 (5): 541–54. 

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Détomidine — Général Nom IUPAC 4 [(2,3 diméthylphényl) méthyl] 3H imidazole No CAS …   Wikipédia en Français

  • detomidine — de·to·mi·dine (de toґmĭ dēn) an analgesic and sedative used in horses …   Medical dictionary

  • 76631-46-4 — Détomidine Détomidine Général Nom IUPAC 4 [(2,3 diméthylphényl) méthyl] 3H imidazole No CAS …   Wikipédia en Français

  • Dexmedetomidine — Systematic (IUPAC) name (S) 4 [1 (2,3 dimethylphenyl)ethyl] 3H imidazole Clinical data AHFS/Drugs …   Wikipedia

  • Adrenergic receptor — Epinephrine Norepinephrine The adrenergic receptors (or adrenoceptors) are a class of met …   Wikipedia

  • Mirtazapine — Systematic (IUPAC) name …   Wikipedia

  • Amitriptyline — Systematic (IUPAC) name …   Wikipedia

  • Hydroxyzine — Systematic (IUPAC) name (±) 2 (2 {4 [(4 chlorophenyl) phe …   Wikipedia

  • Doxepin — mixture of cis and trans isomers Systematic (IUPAC) name (E/Z) 3 (dibenzo[b,e]oxepin 11(6H) ylidene) N,N dimethylpropan 1 amine …   Wikipedia

  • Trazodone — Systematic (IUPAC) name 2 {3 [4 (3 chloro …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.