Vesicular monoamine transporter

The vesicular monoamine transporter is a transport protein located within the presynaptic cell. It acts upon synaptic vesicles.


It comprises the two isoforms:


Substrates for the transporter is mainly noradrenaline, adrenaline and isoprenaline. However, other substrates include dopamine, 5-HT, guanethidine and MPP+. cite book |author=Rang, H. P. |title=Pharmacology |publisher=Churchill Livingstone |location=Edinburgh |year=2003 |pages= |isbn=0-443-07145-4 |oclc= |doi= Page 167 ]

Clinicial significance

It can be inhibited by reserpine and tetrabenazine.

VMAT is the main target of methamphetamine. By acting as a competitive antagonist, methamphetamine blocks the presynaptic cell's ability to use VMAT to package the above mentioned neurotransmitters into vesicles. The result is increased neurotransimtter release that is not dependent on the phasic activity of the presynaptic cell.


Further reading

*cite journal |author=Kilbourn MR |title=In vivo radiotracers for vesicular neurotransmitter transporters |journal=Nucl. Med. Biol. |volume=24 |issue=7 |pages=615–9 |year=1997 |pmid=9352531 |doi=10.1016/S0969-8051(97)00101-7


External links


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Monoamine transporter — Dopamine Transporter (DAT 6) Monoamine transporters (MATs) are protein structures that function as integral plasma membrane transporters to regulate concentrations of extracellular monoamine neurotransmitters. Three major classes of MATs (SERT,… …   Wikipedia

  • Monoamine oxidase inhibitor — MAOI redirects here. For the Easter Island statues, see Moai. Monoamine oxidase Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. They are particularly effective in treating… …   Wikipedia

  • Monoamine neurotransmitter — Norepinephrine is a monoamine neurotransmitter …   Wikipedia

  • Neurotransmitter transporter — Neurotransmitter transporters are a class of membrane transport proteins that span the cellular membranes of neurons. Their primary function is to carry neurotransmitters across these membranes and to direct their further transport to specific… …   Wikipedia

  • Dopamine transporter — Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Identifiers Symbols …   Wikipedia

  • Norepinephrine transporter — Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Identifiers Symbols SLC6A2; NAT1; NET; NET1; SLC6A5 External IDs …   Wikipedia

  • Choline transporter — The high affinity choline transporter (ChT) is a protein encoded by the human gene SLC5A7. It is a plasmalemmal transporter and carries choline into acetylcholine synthesizing neurons. Hemicholinium 3 is an inhibitor of the ChT and can be used to …   Wikipedia

  • Nucleoside transporter — Nucleoside transporters (NTs) are a group of membrane transport proteins which transport nucleoside substrates like adenosine across the membranes of cells and/or vesicles.[1] There are two known types of nucleoside transporters, concentrative… …   Wikipedia

  • Reuptake inhibitor — Escitalopram, a selective serotonin reuptake inhibitor (SSRI) used as an antidepressant. A reuptake inhibitor (RI), also known as a transporter blocker, is a drug that inhibits the plasmalemmal transporter mediated reuptake of a neurotransmitter… …   Wikipedia

  • Releasing agent — Amphetamine, the prototypical releasing agent, which acts on norepinephrine and dopamine. A releasing agent (RA), or simply releaser, is a drug that induces the release of a neurotransmitter from the presynaptic neuron into the synapse, leading… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.