Vesicular monoamine transporter
The vesicular monoamine transporter is a
transport proteinlocated within the presynaptic cell. It acts upon synaptic vesicles.
It comprises the two isoforms:
Substrates for the transporter is mainly
noradrenaline, adrenalineand isoprenaline. However, other substrates include dopamine, 5-HT, guanethidineand MPP+. cite book |author=Rang, H. P. |title=Pharmacology |publisher=Churchill Livingstone |location=Edinburgh |year=2003 |pages= |isbn=0-443-07145-4 |oclc= |doi= Page 167 ]
It can be inhibited by
reserpineand tetrabenazine. VMATis the main target of methamphetamine. By acting as a competitive antagonist, methamphetamine blocks the presynaptic cell's ability to use VMAT to package the above mentioned neurotransmitters into vesicles. The result is increased neurotransimtter release that is not dependent on the phasic activity of the presynaptic cell.
*cite journal |author=Kilbourn MR |title=In vivo radiotracers for vesicular neurotransmitter transporters |journal=Nucl. Med. Biol. |volume=24 |issue=7 |pages=615–9 |year=1997 |pmid=9352531 |doi=10.1016/S0969-8051(97)00101-7
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