Small Nucleolar RNA SNORD64
SNORD64 (also known as HBII-13) is a
non-coding RNA(ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolusof the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
SNORD64 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-
methylationof substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] .
snoRNA HBII-13 is expressed mainly in the tissues of brain, but is also in the lungs, the kidneys and muscle cite journal | last = Cavaille | first = J | coauthors = Buiting K, Kiefmann M, Lalande M, Brannan CI, Horsthemke B, Bachellerie JP, Brosius J, Huttenhofer A | year = 2000 | title = Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization | journal = Proc Natl Acad Sci U S A. | volume = 97 | pages = 14311–14316 | pmid = 11106375 | doi = 10.1073/pnas.250426397] however HBII-13 has no identified target RNA cite journal | last = Lestrade | first = L | coauthors = Weber MJ | year = 2006 | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | journal = Nucleic Acids Res. | volume = 34 | pages = D158–D162 | pmid = 16381836 | doi = 10.1093/nar/gkj002 ] . The HBII-13 gene is located in in a 460 kb
intronof the large, paternally expressed, transcription unit (SNURF-SNRNP-UBE3A AS) along with several other snoRNAs HBII-436, HBII-437, HBII-438A/B and the clusters of HBII-85, HBII-52 cite journal | last = Runte | first = M | coauthors = Huttenhofer A, Gross S, Kiefmann M, Horsthemke B, Buiting K | year = 2001 | title = The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A | journal = Hum Mol Genet. | volume = 10 | pages = 2687–2700 | pmid = 11726556 | doi = 10.1093/hmg/10.23.2687] . This host gene is an antisense transcript to maternally expressed UBE3A gene.
* [http://www-snorna.biotoul.fr/plus.php?id=HBII-13 snoRNABase entry for SNORD64]
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