Small nucleolar RNA SNORD63
snoRNA U63 (also known as SNORD63) is a
non-coding RNA(ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolusof the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
snoRNA U63 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-
methylationof substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] .
snoRNA U63 was purified from
HeLacells by immunoprecipitation with antifibrillarin antibody. It is predicted to guide the 2'-O-ribose methylation of 28s ribosomal RNA (rRNA) at residue A4531cite journal | author = Tycowski KT, Smith CM, Shu MD, Steitz JA | title = A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 25 | pages = 14480–5 | year = 1996 | pmid = 8962077 | doi = | issn = ] .
* [http://www-snorna.biotoul.fr/plus.php?id=U62 snoRNABase entry for SNORD62]
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