Triamcinolone


Triamcinolone
Triamcinolone
Systematic (IUPAC) name
(11β,16α)-9-fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Clinical data
Trade names Kenalog
AHFS/Drugs.com monograph
Pregnancy cat. A(AU) C(US)
Legal status POM (UK) -only (US)
Routes Oral, topical, IM, intra-articular, intrasynovial
Pharmacokinetic data
Protein binding 68%
Metabolism Hepatic
Half-life 88 minutes
Excretion Fecal and renal
Identifiers
CAS number 124-94-7
ATC code A01AC01 C05AA12, D07AB09, D07XB02, H02AB08, R01AD11, R03BA06, S01BA05
PubChem CID 31307
DrugBank APRD00422
ChemSpider 29046 YesY
UNII 1ZK20VI6TY YesY
KEGG D00385 YesY
ChEMBL CHEMBL1451 YesY
Synonyms
Chemical data
Formula C21H27FO6 
Mol. mass 394.434 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Triamcinolone (trade names Aristocort, Kenacort, Tri-Nasal, Triaderm, Azmacort, Trilone, Volon A, Tristoject, and Tricortone) is a long-acting synthetic corticosteroid given orally, by injection, inhalation, or as a topical ointment or cream.

Contents

Uses

Triamcinolone is used to treat several different medical conditions, such as eczema, psoriasis, arthritis, allergies, ulcerative colitis, lupus, sympathetic ophthalmia, temporal arteritis, uveitis, and ocular inflammation, visualization during vitrectomy and the prevention of asthma attacks. It will not treat an asthma attack once it has already begun.[1][2][3]

Prior to 2007 it was manufactured under the name Azmacort as a corticosteroid inhaler for asthma long-term care. The patent holder, Sanofi, sold it under the brand name Nasacort.

In 2010, TEVA and Perrigo launched the first generic inhalable triamcinolone.[4]

Triamcinolone is used to alleviate infection-induced eczema in fungal skin infections in the combination drug of econazole/triamcinolone.

Triamcinolone acetonide is one of the ingredients of Ledermix - an endodontic (tooth's root canal) lotion used between sessions.

Forms

Different triamcinolone salts are available, including acetonide, benetonide, furetonide, hexacetonide and diacetate.

Triamcinolone acetonide is a more potent type of triamcinolone, being about eight times as effective as prednisone.

Side effects

Side effects of Triamcinolone include sore throat, nosebleeds, increased coughing, headache, and runny nose. White patches in the throat or nose indicate a serious side effect. Symptoms of an allergic reaction include rash, itch, swelling, severe dizziness, trouble breathing.[5] An additional side effect for women is a prolonged menstrual cycle.

References

Aristocort (triamcinolone) topical cream (AU)
Kenalog (triamcinolone) IM injection (SCO)
  1. ^ Triamcinolone - Drugs.com
  2. ^ Triamcinolone Inhalation - Drugs.com
  3. ^ Alcon Receives FDA Approval of Triesence Injectable Triamcinolone Suspension for Use in Eye Surgery - Drugs.com
  4. ^ Perrigo Announces Launch Of Generic Version Of Nasacort AQ - CBS Detroit
  5. ^ "Drugs and Treatments - Nasacort AQ Nasl - Patient Handout". WebMD. http://www.webmd.com/drugs/drug-16244-Nasacort+AQ.aspx?drugid=16244&drugname=Nasacort%20AQ. Retrieved 2008-03-24. 

External links


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • triamcinolone — ● triamcinolone nom féminin Dérivé fluoré de la prednisolone, doué d une activité anti inflammatoire six fois supérieure à celle de la cortisone …   Encyclopédie Universelle

  • triamcinolone — noun Etymology: tri + amcin (alteration of American Cyanimid Company) + 1 ol + one Date: 1957 a glucocorticoid drug C21H27FO6 used chiefly in the form of its acetal or acetate derivatives especially in treating skin disorders, asthma, and… …   New Collegiate Dictionary

  • triamcinolone — /truy am sin euh lohn /, n. Pharm. a synthetic glucocorticoid drug, C21H27FO6, used in the symptomatic treatment of inflammation. [1955 60; triamcin (of unexplained derivation) + (PREDNIS)OLONE] * * * …   Universalium

  • triamcinolone — noun A certain synthetic corticosteroid …   Wiktionary

  • triamcinolone — A glucocorticoid with actions and uses similar to those of prednisolone. t. acetonide a potent glucocorticoid for topical treatment of dermatoses. t. diacetate an anti inflammatory and antiallergic agent for parenteral use. * …   Medical dictionary

  • triamcinolone — tri·am·cin·o·lone …   English syllables

  • triamcinolone — n. a synthetic corticosteroid hormone that reduces inflammation but does not cause salt and water retention. It is used for treating a wide range of inflammatory and allergic conditions, including rheumatoid arthritis, eczema, psoriasis, and hay… …   The new mediacal dictionary

  • triamcinolone — tri•am•cin•o•lone [[t]ˌtraɪ æmˈsɪn əˌloʊn[/t]] n. pha a synthetic glucocorticoid drug, C21H27FO6, used in the symptomatic treatment of inflammation • Etymology: 1955–60; triamcin (of undetermined derivation) + (prednis) olone …   From formal English to slang

  • triamcinolone — A substance that is being studied for the prevention of nonmelanoma skin cancer. It is an anti inflammatory drug that is applied to the skin to relieve irritation, rashes, and infections. It belongs to the family of drugs called topical… …   English dictionary of cancer terms

  • triamcinolone — noun a synthetic corticosteroid (trade names Aristocort or Aristopak or Kenalog) used as an anti inflammatory agent (Freq. 4) • Syn: ↑Aristocort, ↑Aristopak, ↑Kenalog • Usage Domain: ↑trade name (for: ↑ …   Useful english dictionary


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.