IUPAC_name = "2-((1"S",6"S")-3-methyl-6-(prop-1-en-2-yl)

width = 240

width2 = 240
CAS_number = 13956-29-1
ATC_prefix = no
ATC_suffix = entry
PubChem = 644019
DrugBank = none
molecular_weight = 314.46
melting_point = 66
smiles = CCCCCC(C=C1O)=CC(O)=C1 [C@] 2
(C=C(C)CC [C@] 2( [H] )C(C)=C) [H]
bioavailability =
metabolism =
elimination_half-life =
excretion =
pregnancy_category =
legal_status = Schedule I (US)
routes_of_administration =

Cannabidiol, also known as CBD, is a cannabinoid found in "Cannabis". It is a major constituent of the plant, representing up to 40% in its extracts.cite journal
last =Grlie
first = L
authorlink =
coauthors =
title =A comparative study on some chemical and biological characteristics of various samples of cannabis resin
journal =Bulletin on Narcotics
volume =14
issue =
pages =37–46
publisher =
date = 1976
url =
doi =
id =
accessdate =

CBD alone is not intoxicating, but it appears to moderate the euphoric effect of tetrahydrocannabinol (THC), which is an isomer of cannabidiol and add a sedative quality.cite journal
author=Pickens JT
title=Sedative activity of cannabis in relation to its delta'-trans-tetrahydrocannabinol and cannabidiol content
journal=Br. J. Pharmacol.
] Some research, however, indicates that CBD can increase alertness. [cite journal
last = Nicholson
first = AN
authorlink =
coauthors = C Turner, BM Stone, and PJ Robson
year = 2004
month = June
title = Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults
journal = J Clin Psychopharmacol
volume = 24
issue = 3
pages = 305–13
issn = 0271-0749
pmid = 15118485
url =
format = fee required
accessdate = 2007-05-03
doi = 10.1097/
] It may decrease the rate of THC clearance from the body, perhaps by interfering with the metabolism of THC in the liver. CBD does not appear to affect either the CB1 or CB2 receptors. [cite journal
last = Straus
first = Stephen E.
authorlink =
coauthors =
title = Immunoactive cannabinoids: Therapeutic prospects for marijuana constituents
journal = Proc Natl Acad Sci U S A.
volume = 97
issue = 17
pages = 9363–9364
publisher =
date = 15 August 2000
url =
doi =10.1073/pnas.180314297
id =
accessdate =
pmid = 10931962

Medically, it appears to relieve convulsion, inflammation, anxiety, and nausea, and to inhibit cancer cell growth. [cite journal
author=Mechoulam R, Peters M, Murillo-Rodriguez E, Hanus LO
title=Cannabidiol - recent advances
journal=Chemistry & Biodiversity
] Recent studies have shown cannabidiol to be as effective as atypical antipsychotics in treating schizophrenia. [cite journal
last = Zuardi
first = A.W
coauthors = J.A.S. Crippa, J.E.C. Hallak, F.A. Moreira, F.S. Guimarães
title = Cannabidiol as an antipsychotic drug
journal = Brazilian Journal of Medical and Biological Research
date = 2006
volume = 39
pages = 421–429
url =
issn = ISSN 0100-879X
] In November 2007 it was reported that CBD reduces growth of aggressive human breast cancer cells "in vitro" and reduces their invasiveness. It thus represents the first non-toxic exogenous agent that can lead to down-regulation of tumor aggressiveness. [ [ Article] on BBC site] It is also a neuroprotective antioxidant. [ Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants] , A. J. Hampson, M. Grimaldi, J. Axelrod, and D. Wink, Proc Natl Acad Sci U S A. 1998 July 7; 95(14): 8268–8273.]

Medicinal use

In April 2005, Canadian authorities approved the marketing of Sativex, a mouth spray for multiple sclerosis to alleviate pain. Sativex contains tetrahydrocannabinol together with cannabidiol. It is marketed in Canada by GW Pharmaceuticals.

Initial research is showing that CBD has an effect in reducing schizophrenic symptoms in patients, but much more research is needed before any link is confirmed, let alone it being developed into an anti-psychotic medication. [cite journal
last = Zuardi
first = A.W
coauthors = J.A.S. Crippa, J.E.C. Hallak, F.A. Moreira, F.S. Guimarães
title = Cannabidiol as an antipsychotic drug
journal = Brazilian Journal of Medical and Biological Research
volume = 39
pages = 421–429
url =
issn = ISSN 0100-879X


Cannabidiol does not bind to CB1 or CB2 receptors but it does block the effects of cannabinoid agonists by an unknown indirect way. [cite journal
author=Thomas A, Baillie GL, Phillips AM, Razdan RK, Ross RA, Pertwee RG
title=Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
journal=Br. J. Pharmacol.
issue=5 |pages=613–23
] Recently it was found to be an antagonist at the putative new cannabinoid receptor, GPR55, a GPCR expressed in the caudate nucleus and putamen. [cite journal
author=Ryberg E, Larsson N, Sjögren S, "et al"
title=The orphan receptor GPR55 is a novel cannabinoid receptor
journal= British Journal of Pharmacology
volume= 152
pages= 1092

Cannabidiol has also been shown to inhibit cancer cell growth, with low potency in non-cancer cells. Although the inhibitory mechanism is not yet fully understood, Ligresti et al suggest that "cannabidiol exerts its effects on these cells through a combination of mechanisms that include either direct or indirect activation of CB2 and TRPV1 receptors, and induction of oxidative stress, all contributing to induce apoptosis."cite journal
author=Ligresti A, Moriello AS, Starowicz K, "et al"
title=Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
journal=J. Pharmacol. Exp. Ther.
] In November 2007, researchers at the California Pacific Medical Center reported that CBD shows promise for controlling the spread of metastatic breast cancer. "In vitro" CBD downregulates the activity of the gene Id-1 which is responsible for tumor metastasis.cite journal
author=McAllister SD, Christian RT, Horowitz MP, Garcia A, Desprez PY
title=Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
journal=Mol. Cancer Ther.


Cannabidiol is insoluble in water but soluble in organic solvents. At room temperature it is a colorless crystalline solid. [cite journal
author=Jones PG, Falvello L, Kennard O, Sheldrick GM Mechoulam R
journal= Acta Cryst.
volume= B33
pages= 3211–3214
] In strongly basic medium and the presence of air it is oxidized to a quinone. [cite journal
author=Mechoulam R, Ben-Zvi Z
title=Hashish—XIII On the nature of the beam test
journal= Tetrahedron
volume= 24
pages= 5615–5624
] Under acidic conditions it cyclizes to THC. [cite journal
author=Gaoni Y, Mechoulam R
title=Hashish—VII The isomerization of cannabidiol to tetrahydrocannabinols
journal= Tetrahedron
volume= 22
pages= 1481–1488
] The synthesis of cannabidiol has been accomplished by several research groups. [cite journal
author=Petrzilka T, Haefliger W, Sikemeier C, Ohloff G, Eschenmoser A
title=Synthese und Chiralität des (-)-Cannabidiols
journal= Helv. Chim. Acta
volume= 50
pages= 719–723
] [cite journal
author=Gaoni Y, Mechoulam R
title=Boron trifluoride etherate on alumuna - a modified Lewis acid reagent. An improved synthesis of cannabidiol
journal= Tetrahedron Letters
volume= 26
pages= 1083–1086
] [cite journal
author=Kobayashi Y, Takeuchi A, Wang YG
title=Synthesis of cannabidiols via alkenylation of cyclohexenyl monoacetate
journal=Org. Lett.
pages=2699–2702 |year=2006 |pmid=16774235

Legal Status

Cannabidiol is a Schedule I drug in the USA, despite having no psychoactive effects and no known abuse potential.


See also

* Cannabinoids
* Cannabinoid receptors
* Cannabis
* Health issues and the effects of cannabis
* Medical marijuana

External links

* [ Erowid] Compounds found in "Cannabis sativa"

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  • Cannabidiol — Saltar a navegación, búsqueda El Cannabidiol (CBD) es un narcótico o estupefaciente, una sustancia medicinal que provoca cansancio general y, en la mayoría de los casos, inhibe la transmisión de señales nerviosas asociadas al dolor. Es el… …   Wikipedia Español

  • Cannabidiol — Strukturformel Allgemeines Name Cannabidiol (CBD) Andere Namen …   Deutsch Wikipedia

  • Cannabidiol — Cannabinoïde Les cannabinoïdes sont un groupe de substances chimiques qui activent les récepteurs cannabinoïdes présents dans le corps. Il existe trois types de cannabinoïdes : les cannabinoïdes végétaux (phytocannabinoïdes), présents dans… …   Wikipédia en Français

  • cannabidiol — can·na·bi·di·ol (kăn ə bĭ dīʹôl , ōl , ŏl ) n. A chemical constituent of cannabis, C21H28(OH)2.   [cannabis + di 1 + ol1.] * * * …   Universalium

  • cannabidiol — noun A non psychoactive cannabinoid found in the hemp plant Cannabis sativa …   Wiktionary

  • cannabidiol — A constituent of Cannabis, related to cannabinol. * * * can·na·bi·di·ol .kan ə bə dī .ȯl, kə nab ə , .ōl n a crystalline diphenol C21H28(OH)2 obtained from the hemp plant that is physiologically inactive but is rearranged by acids into THC * * * …   Medical dictionary

  • cannabidiol —    A constituent of cannabis …   Forensic science glossary

  • cannabidiol — can·na·bi·di·ol …   English syllables

  • cannabidiol — /kænəˈbɪdiɒl/ (say kanuh bideeol) noun a component of marijuana. {cannabi(s) + di 1 + ol1} …   Australian English dictionary

  • cannabidiol — |kanəbə̇ˈdīˌȯl, ˌōl noun ( s) Etymology: New Latin Cannabis (genus name of Cannabis sativa) + English diol : a crystalline diphenol C21H28(OH)2 that is obtained from the resin of the hemp plant and is physiologically inactive but is rearranged… …   Useful english dictionary

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