Triple bolus test
A triple bolus test or a dynamic pituitary function test is a medical diagnostic procedure used to assess a patient's
pituitary function. Three hormones (usually synthetic analogues) are injected as a bolus into the patient's vein to stimulate theanterior pituitary gland:insulin ,gonadotropin-releasing hormone (GnRH), andthyrotropin-releasing hormone (TRH). The gland's response is assessed by measuringcortisol ,growth hormone (GH),prolactin ,thyroid-stimulating hormone (TSH),luteinizing hormone (LH) andfollicle-stimulating hormone (FSH) hormone levels. Bloodglucose levels are also monitored forhypoglycemia . A triple bolus test is usually ordered and interpreted by endocrinologists.The triple bolus test was introduced in 1973 by physicians from the London
Royal PostgraduateMedical School andQueen Elizabeth Hospital, Birmingham . [cite journal |author=Harsoulis P, Marshall JC, Kuku SF, Burke CW, London DR, Fraser TR |title=Combined test for assessment of anterior pituitary function |journal=Br Med J |volume=4 |issue=5888 |pages=326–9 |year=1973 |month=November |pmid=4202260 |pmc=1587416] It followed earlier reports combining insulin andvasopressin analogues in the diagnosis of hypopituitarism. [cite journal |author=Greenwood FC, Landon J |title=Assessment of hypothalamic pituitary function in endocrine disease |journal=J. Clin. Pathol. |volume=19 |issue=3 |pages=284–92 |year=1966 |month=May |pmid=4287115 |pmc=473256 |doi= |url=http://jcp.bmj.com/cgi/reprint/19/3/284]ee also
*
Hypopituitarism
*Insulin tolerance test References
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