Indatraline

Drugbox
IUPAC_name = (1R,3S)-3-(3,4-dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-amine


width= 150
CAS_number= 86939-10-8
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PubChem= 126280
DrugBank=
C=16 | H=15 | Cl=2 | N=1
molecular_weight = 292.2072 g/mol
bioavailability=
metabolism =
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pregnancy_category =
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Indatraline, also known as Lu 19-005, is a nonselective monoamine reuptake inhibitor that has been shown to block the reuptake of dopamine, norepinephrine, and serotonin with effects similar to those of cocaine. However, the effects have been shown to have slower onset and longer duration than cocaine, suggesting that the compound may, along with similar compounds, be used for treatment of cocaine abuse. [Negus SS, Brandt MR, Mello NK. "Effects of the long-acting monoamine reuptake inhibitor indatraline on cocaine self-administration in rhesus monkeys." J Pharmacol Exp Ther (1999) 291(1):60-9. [http://jpet.aspetjournals.org/cgi/content/abstract/291/1/60] ] Research has also suggested that indatraline can be used to block the action of methamphetamine. [Rothman, B. R. eta al, "Neurochemical Neutralization of Methamphetamine With High-Affinity Nonselective Inhibitors of Biogenic Amine Transporters: A Pharmacological Strategy for Treating Stimulant Abuse." Synapse (2000) 35:222-227. [http://www3.interscience.wiley.com/cgi-bin/abstract/69502576/ABSTRACT] ]

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