ABCC4

ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Identifiers
Symbols ABCC4; EST170205; MOAT-B; MOATB; MRP4
External IDs OMIM605250 MGI2443111 HomoloGene74563 GeneCards: ABCC4 Gene
Orthologs
Species Human Mouse
Entrez 10257 239273
Ensembl ENSG00000125257 ENSMUSG00000032849
UniProt O15439 Q3TZN9
RefSeq (mRNA) NM_001105515.1 NM_001033336
RefSeq (protein) NP_001098985.1 NP_001028508
Location (UCSC) Chr 13:
95.67 – 95.95 Mb
Chr 14:
118.88 – 119.11 Mb
PubMed search [1] [2]

ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ABCC4 gene.[1][2]

ABCC4 acts as a regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus.[3]

Contents

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective Wikipedia articles. [4]

[[File:
FluoropyrimidineActivity_WP1601 go to article go to article go to article go to article go to article go to article go to article go to article start new article go to article go to article go to article go to article start new article go to article start new article go to article go to article go to article go to article go to article go to article start new article go to article go to article go to article go to article go to article Go to HMDB Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
FluoropyrimidineActivity_WP1601 go to article go to article go to article go to article go to article go to article go to article go to article start new article go to article go to article go to article go to article start new article go to article start new article go to article go to article go to article go to article go to article go to article start new article go to article go to article go to article go to article go to article Go to HMDB Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
|{{{bSize}}}px]]
Fluorouracil (5-FU) Activity edit

See also

References

  1. ^ "Entrez Gene: ATP-binding cassette". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10257. 
  2. ^ Lee K, Belinsky MG, Bell DW, Testa JR, Kruh GD (July 1998). "Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter". Cancer Res. 58 (13): 2741–7. PMID 9661885. 
  3. ^ Sassi Y, Lipskaia L, Vandecasteele G, Nikolaev VO, Hatem SN, Cohen Aubart F, Russel FG, Mougenot N, Vrignaud C, Lechat P, Lompré AM, Hulot JS (August 2008). "Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation". J. Clin. Invest. 118 (8): 2747–57. doi:10.1172/JCI35067. PMC 2467383. PMID 18636120. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2467383. 
  4. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601". http://www.wikipathways.org/index.php/Pathway:WP1601. 

Further reading

External links