Azaperone

drugbox
IUPAC_name = 1-(4-fluorophenyl)-4-(4-pyridin-2-ylpiperazin-1-yl)butan-1-one



width = 180
CAS_number = 1649-18-9
ATC_prefix =
ATC_suffix =
PubChem = 15443
C=19 | H=22 | F=1 | N=3 | O=1
molecular_weight = 327.396 g/mol
smiles = C1CN(CCN1CCCC(=O)C2=CC=C(C=C2)F)C3=CC=CC=N3
melting_point = 90
melting_high = 95
bioavailability =
protein_bound =
metabolism = hepatic
elimination_half-life = 4 hours
excretion =
pregnancy_AU =
pregnancy_US =
pregnancy_category =
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status =
routes_of_administration = intramuscular injection

Azaperone (Stresnil, Fluoperidol) is a butyrophenone neuroleptic drug with sedative and anti-emetic effects, which is used mainly as a tranquilizer in veterinary medicine. It is used mainly in pigs and elephants. [http://www.elephantcare.org/Drugs/azaperon.htm] More rarely it may be used in humans as an antipsychotic drug, but this is uncommon. Use in horses is avoided as adverse reactions may occur.

Azaperone acts primarily as a dopamine antagonist but also has some antihistaminic and anticholinergic properties as seen with similar drugs such as haloperidol. Azaperone may cause hypotension and while it has minimal effects on respiration in pigs, high doses in humans can cause respiratory depression which may be why it is rarely used in humans.

The most common use for azaperone is in relatively small doses to reduce aggression in farmed pigs, either to stop them fighting or to encourage sows to accept piglets. Higher doses are used for anesthesia in combination with other drugs such as xylazine, tiletamine and zolazepam. Azaperone is also used in combination with strong narcotics such as etorphine or carfentanil for tranquilizing large animals such as elephants.


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • azaperone — A tranquilizing agent. * * * aza·per·one (a″zə perґōn) [USP] a butyrophenone antipsychotic used as a tranquilizer in veterinary medicine …   Medical dictionary

  • Clozapine — Not to be confused with clonazepam or Klonopin. Clozapine Systematic (IUPAC) name …   Wikipedia

  • Trifluoperazine — Systematic (IUPAC) name 10 [3 (4 methylpiperazin 1 yl)propyl] 2 (trifluoromethyl) 10H phenothiazine Clinical data AHFS/ …   Wikipedia

  • Fluphenazine — Systematic (IUPAC) name 2 [4 [3 [2 (trifluoromethyl) 10H phenothiazin 10 yl]propyl]piperazin 1 yl]ethanol Clinical data …   Wikipedia

  • Olanzapine — Systematic (IUPAC) name 2 methyl 4 (4 methyl …   Wikipedia

  • Perphenazine — Systematic (IUPAC) name 2 [4 [3 (2 chloro 10H phenothiazin 10 yl) propyl]piperazin 1 yl]ethanol Clinical data AHFS/Drugs.com …   Wikipedia

  • Aripiprazole — Systematic (IUPAC) name 7 {4 [4 (2,3 dichlorophenyl)piperazin 1 yl]butoxy} 3,4 dihydroquinolin 2(1H) one Clinical data Trade names …   Wikipedia

  • Loxapine — Systematic (IUPAC) name 2 Chloro 11 (4 methylpiperazin 1 yl)dibenzo[b,f][1,4]oxazepine Clinical data AHFS/Drugs.com …   Wikipedia

  • Amoxapine — Systematic (IUPAC) name 2 Chloro 11 (piperazin 1 yl)dibenzo[b,f][1,4]oxazepine Clinical data Trade names Asendin …   Wikipedia

  • Prochlorperazine — Systematic (IUPAC) name 2 chloro 10 [3 (4 methyl 1 piperazinyl)propyl] 10H phenothiazine Clinical data AHFS/ …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.