Idiotype

In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T cell receptor (TCR) molecules based upon the antigen binding specificity and therefore structure of their variable region. The variable region of antigen receptors of T cells (TCRs) and B cells (immunoglobulins) contains a complementarity determining region (CDR) with a unique amino acid structure that determines the antigen specificity of the receptor. The structure formed by the CDR is known as the idiotope. Immunoglobulins or TCRs with a shared idiotope are the same idiotype. Antibody idiotype is determined by
*Gene rearrangement
*Junctional diversity
*P-nucleotides (palindromic nucleotides at sites of single-strand breaks)
*N-nucleotides
*Somatic hypermutations

The term idiotype is sometimes used to describe the collection of multiple idiotopes, and therefore overall antigen binding capacity, possessed by an antibody.

ee also

* immunoglobulin allotype
* Isotype (immunology)

External links

*
*
* [http://pathmicro.med.sc.edu/mayer/IgTypes2000.htm Overview] at Medical University of South Carolina
* [http://www.cehs.siu.edu/fix/medmicro/igs.htm Overview] at Southern Illinois University Carbondale


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  • idiotype — idiotype. См. идиотип. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Idiotype — L idiotype, du grec particulier, forme , est une caractéristique retrouvée chez de rares individus d une même espèce. Cette notion a été développée, par Jacques Oudin (biologiste) en particulier, lors de l étude des spécificités antigéniques des… …   Wikipédia en Français

  • idiotype — The antigenic specificities defined by the unique sequences (idiotopes) of the antigen combining site. Thus anti idiotype antibodies combine with those specific sequences, may block immunological reactions, and may resemble the epitope to which… …   Dictionary of molecular biology

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  • idiotype — An identifying property or characteristic of an item or system. 1.A plant form expected on physiological grounds to represent an optimal type for the environment in which the plant is to be grown. 2. A classification of antibody molecules… …   Glossary of Biotechnology

  • idiotype — noun Date: 1960 the molecular structure and conformation of an antibody that confers its antigenic specificity • idiotypic adjective …   New Collegiate Dictionary

  • idiotype — ideotype …   Dictionary of ichthyology

  • idiotype — n. [Gr. idios, personal; typos, type] Genotype; idioplasm …   Dictionary of invertebrate zoology

  • idiotype — (id e o taīp ) A set of one or more unique epitopes in the variable region of an immunoglobulin that distinguishes it from immunoglobulins produced by different plasma cells …   Dictionary of microbiology

  • idiotype — idiotypic /id ee euh tip ik/, adj. idiotypy /id ee euh tuy pee/, n. /id ee euh tuyp /, n. Immunol. the molecular arrangement of amino acids unique to the antigen binding site of a particular antibody. [1969; back formation from idiotypic or… …   Universalium

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