Transient tachypnea of the newborn
Name = PAGENAME
DiseasesDB = 32373
ICD10 = ICD10|P|22|1|p|20
ICD9 = ICD9|770.6
MedlinePlus = 007233
eMedicineSubj = ped
eMedicineTopic = 2597
eMedicine_mult = eMedicine2|radio|710
Transient tachypnea of the newborn (TTN, TTNB, or "Transitory tachypnea of newborn") is a respiratory problem seen in the
newbornshortly after delivery. It consists of a period of rapid breathing (higher than the normal range of 40-60 times per minute). It is likely due to retained lungfluid, and common in 35+ week gestation babies who are delivered by caesarian sectionwithout labour. Usually, this condition resolves over 24-48 hours. Treatment is supportive and may include supplemental oxygenand antibiotics. The chest X-Rayshows hyperinflation of the lungs including prominent pulmonary vasular markings, flattening of the diaphragm, and fluid in the horizontal fissure.
# Due to the higher incidence of TTN in newborns delivered by caesarean section, it has been postulated that TTN could result from a delayed absorption of fetal lung fluid from the pulmonary lymphatic system. The increased fluid in the lungs leads to increased airway resistance and reduced lung compliance. It is thought this could be from lower levels of circulating
catecholamines after a caesarean section and that these are necessary to alter the function of the ENaC channel to absorb excess fluid from the lungs.
# Pulmonary immaturity has also been proposed as a causative factor. Levels of
phosphatidylglycerol(an indicator of lung maturity) was found to be negative in certain newborns.
# Mild surfactant deficiency has also been suggested as a causative factor.
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