Stem cell factor

Stem cell factor (SCF), otherwise known as KIT ligand or Steel factorFreshney, Ian R. "Culture of Animal Cells: A manual of basic technique". John Wiley & Sons, Inc., Hoboken, New Jersey. ISBN 13 978-0-471-45329-1] ,is a cytokine which binds CD117 (c-Kit). SCF is also known as "steel factor" or "c-kit ligand". SCF exists in two forms, cell surface bound SCF and soluble (or free) SCF. Soluble SCF is produced by the cleavage of surface bound SCF by metalloproteases.

SCF is a growth factor important for the survival, proliferation, and differentiation of hematopoietic stem cells and other hematopoietic progenitor cells. One of its roles is to change the BFU-E(burst-forming unit-erythroid) cells, which are the earliest erythrocyte precursors in the erythrocytic series, into the CFU-E (colony-forming unit-erythroid) [Dorlands|u_02|12836993] . SCF, along with bFGF (basic fibroblast growth factor) and LIF (lymphocyte inhibitory factor), prevents spontaneous differentiation of primitive embryonic stem cells in cell cultureFreshney, Ian R. "Culture of Animal Cells: A manual of basic technique". John Wiley & Sons, Inc., Hoboken, New Jersey. ISBN 13 978-0-471-45329-1] .

Ancestim is a recombinant form of SCF.cite journal |author=da Silva MG, Pimentel P, Carvalhais A, "et al" |title=Ancestim (recombinant human stem cell factor, SCF) in association with filgrastim does not enhance chemotherapy and/or growth factor-induced peripheral blood progenitor cell (PBPC) mobilization in patients with a prior insufficient PBPC collection |journal=Bone Marrow Transplant. |volume=34 |issue=8 |pages=683–91 |year=2004 |pmid=15322567 |doi=10.1038/sj.bmt.1704602]


Further reading

citations =
*cite journal | author=Broudy VC |title=Stem cell factor and hematopoiesis. |journal=Blood |volume=90 |issue= 4 |pages= 1345–64 |year= 1997 |pmid= 9269751 |doi=
*cite journal | author=Andrews RG, Briddell RA, Appelbaum FR, McNiece IK |title=Stimulation of hematopoiesis in vivo by stem cell factor. |journal=Curr. Opin. Hematol. |volume=1 |issue= 3 |pages= 187–96 |year= 1999 |pmid= 9371281 |doi=
*cite journal | author=Wehrle-Haller B |title=The role of Kit-ligand in melanocyte development and epidermal homeostasis. |journal=Pigment Cell Res. |volume=16 |issue= 3 |pages= 287–96 |year= 2004 |pmid= 12753403 |doi=
*cite journal | author=Rönnstrand L |title=Signal transduction via the stem cell factor receptor/c-Kit. |journal=Cell. Mol. Life Sci. |volume=61 |issue= 19-20 |pages= 2535–48 |year= 2004 |pmid= 15526160 |doi= 10.1007/s00018-004-4189-6
*cite journal | author=Mroczko B, Szmitkowski M |title=Hematopoietic cytokines as tumor markers. |journal=Clin. Chem. Lab. Med. |volume=42 |issue= 12 |pages= 1347–54 |year= 2005 |pmid= 15576295 |doi= 10.1515/CCLM.2004.253
*cite journal | author=Lev S, Yarden Y, Givol D |title=A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses. |journal=J. Biol. Chem. |volume=267 |issue= 15 |pages= 10866–73 |year= 1992 |pmid= 1375232 |doi=
*cite journal | author=Huang EJ, Nocka KH, Buck J, Besmer P |title=Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2. |journal=Mol. Biol. Cell |volume=3 |issue= 3 |pages= 349–62 |year= 1992 |pmid= 1378327 |doi=
*cite journal | author=Toyota M, Hinoda Y, Itoh F, "et al." |title=Expression of two types of kit ligand mRNAs in human tumor cells. |journal=Int. J. Hematol. |volume=55 |issue= 3 |pages= 301–4 |year= 1992 |pmid= 1379846 |doi=
*cite journal | author=Lu HS, Clogston CL, Wypych J, "et al." |title=Post-translational processing of membrane-associated recombinant human stem cell factor expressed in Chinese hamster ovary cells. |journal=Arch. Biochem. Biophys. |volume=298 |issue= 1 |pages= 150–8 |year= 1992 |pmid= 1381905 |doi=
*cite journal | author=Sharkey A, Jones DS, Brown KD, Smith SK |title=Expression of messenger RNA for kit-ligand in human placenta: localization by in situ hybridization and identification of alternatively spliced variants. |journal=Mol. Endocrinol. |volume=6 |issue= 8 |pages= 1235–41 |year= 1992 |pmid= 1383693 |doi=
*cite journal | author=Mathew S, Murty VV, Hunziker W, Chaganti RS |title=Subregional mapping of 13 single-copy genes on the long arm of chromosome 12 by fluorescence in situ hybridization. |journal=Genomics |volume=14 |issue= 3 |pages= 775–9 |year= 1992 |pmid= 1427906 |doi=
*cite journal | author=Geissler EN, Liao M, Brook JD, "et al." |title=Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter. |journal=Somat. Cell Mol. Genet. |volume=17 |issue= 2 |pages= 207–14 |year= 1991 |pmid= 1707188 |doi=
*cite journal | author=Anderson DM, Williams DE, Tushinski R, "et al." |title=Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-q24. |journal=Cell Growth Differ. |volume=2 |issue= 8 |pages= 373–8 |year= 1992 |pmid= 1724381 |doi=
*cite journal | author=Martin FH, Suggs SV, Langley KE, "et al." |title=Primary structure and functional expression of rat and human stem cell factor DNAs. |journal=Cell |volume=63 |issue= 1 |pages= 203–11 |year= 1990 |pmid= 2208279 |doi=
*cite journal | author=Ramenghi U, Ruggieri L, Dianzani I, "et al." |title=Human peripheral blood granulocytes and myeloid leukemic cell lines express both transcripts encoding for stem cell factor. |journal=Stem Cells |volume=12 |issue= 5 |pages= 521–6 |year= 1995 |pmid= 7528592 |doi=
*cite journal | author=Saito S, Enomoto M, Sakakura S, "et al." |title=Localization of stem cell factor (SCF) and c-kit mRNA in human placental tissue and biological effects of SCF on DNA synthesis in primary cultured cytotrophoblasts. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 3 |pages= 1762–9 |year= 1995 |pmid= 7529021 |doi= 10.1006/bbrc.1994.2873
*cite journal | author=Laitinen M, Rutanen EM, Ritvos O |title=Expression of c-kit ligand messenger ribonucleic acids in human ovaries and regulation of their steady state levels by gonadotropins in cultured granulosa-luteal cells. |journal=Endocrinology |volume=136 |issue= 10 |pages= 4407–14 |year= 1995 |pmid= 7545103 |doi=
*cite journal | author=Blechman JM, Lev S, Brizzi MF, "et al." |title=Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor. |journal=J. Biol. Chem. |volume=268 |issue= 6 |pages= 4399–406 |year= 1993 |pmid= 7680037 |doi=
*cite journal | author=Lu HS, Jones MD, Shieh JH, "et al." |title=Isolation and characterization of a disulfide-linked human stem cell factor dimer. Biochemical, biophysical, and biological comparison to the noncovalently held dimer. |journal=J. Biol. Chem. |volume=271 |issue= 19 |pages= 11309–16 |year= 1996 |pmid= 8626683 |doi=
*cite journal | author=Vanhaesebroeck B, Welham MJ, Kotani K, "et al." |title=P110delta, a novel phosphoinositide 3-kinase in leukocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 9 |pages= 4330–5 |year= 1997 |pmid= 9113989 |doi=

External links

* - KEGG pathway: Hematopoietic cell lineage

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