- Protein G
Protein G is an
immunoglobulin-binding protein expressed in group C and G Streptococcalbacteria much like Protein Abut with differing specificities. It is a 65-kDa (G148 protein G) and a 58 kDa (C40 protein G)  cell surface protein that has found application in purifying antibodies through its binding to the Fc region. The native molecule also binds albumin, however, because serum albumin is a major contaminant of antibody sources, the albumin binding site has been removed from recombinantforms of Protein G.
Other antibody binding proteins
In addition to Protein G, other immunoglobulin-binding bacterial proteins such as
Protein A, Protein A/Gand Protein Lare all commonly used to purify, immobilize or detect immunoglobulins. Each of these immunoglobulin-binding proteins has a different antibody binding profile in terms of the portion of the antibody that is recognized and the species and type of antibodies it will bind.
Reflist http://www.jbc.org/cgi/reprint/266/1/399 Sjobring U, Bjorck L, Kastern W, Streptococcal protein G. Gene structure and protein binding properties, J Biol Chem. 1991 Jan 5;266(1):399-405
Wikimedia Foundation. 2010.
Look at other dictionaries:
Protein S — is a vitamin K dependent plasma glycoprotein synthesized in the liver. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b. FunctionThe best characterized function of Protein S is its… … Wikipedia
Protein A — is a 40 60 kDa MSCRAMM surface protein originally found in the cell wall of the bacteria Staphylococcus aureus . It is encoded by the spa gene and its regulation is controlled by DNA topology, cellular osmolarity, and a two component system… … Wikipedia
Protein A/G — is a recombinant fusion protein that combines IgG binding domains of both Protein A and Protein G. Protein A/G contains four Fc binding domains from Protein A and two from Protein G, yielding a final mass of 50,460 daltons. The binding of Protein … Wikipedia
Protein L — is a 36,000 dalton immunoglobulin binding protein isolated from the bacteria Peptostreptococcus magnus . Unlike Protein A and Protein G, which bind to the Fc region of immunoglobilins (antibodies), Protein L binds antibodies through light chain… … Wikipedia
Protein C — Vorhandene Strukturdaten … Deutsch Wikipedia
Protein-C — Vorhandene Strukturdaten: 1aut … Deutsch Wikipedia
Protein Z — protein Name = protein Z caption = width = HGNCid = 9460 Symbol = PROZ AltSymbols = EntrezGene = 8858 OMIM = 176895 RefSeq = NM 003891 UniProt = P22891 PDB = ECnumber = Chromosome = 13 Arm = q Band = 34 LocusSupplementaryData = Protein Z is a… … Wikipedia
Protein — Pro te*in, n. [Gr. prw^tos first: cf. prwtei^on the first place.] (Physiol. Chem.) any polymer of an amino acid joined by peptide (amide) bonds. Most natural proteins have alpha amino acids as the monomeric constituents. All classical enzymes are … The Collaborative International Dictionary of English
Protein-S — Vorhandene Strukturdaten: 1z6c Gr … Deutsch Wikipedia
Protein S — Vorhandene Strukturdaten … Deutsch Wikipedia